Cartridge with multiple electrospray emitters

Patent metadata

Field	Value
Publication number	US-9304116-B2
Application number	US-201214004969-A
Country	US
Kind code	B2
Filing date	Apr 13, 2012
Priority date	Apr 25, 2011
Publication date	Apr 5, 2016
Grant date	Apr 5, 2016

Abstract

An apparatus includes a portable housing and a plurality of separately operable microfluidic emitters disposed within the housing. Each microfluidic emitter h an inlet for receiving a liquid and an outlet for emitting a spray. Each microfluidic emitter is movable within the portable housing between a first position in which the outlet of that microfluidic emitter is fully retracted within the portable housing and a second position in which the outlet of that microfluidic emitter projects out of the portable housing. The portable housing with the multiple emitters is adapted to be detachably coupled to another housing portion. This housing portion includes a microfluidic substrate with a channel for transporting an eluent and an outlet aperture for emitting the eluent. The inlet of one of the emitters is detachably coupled to the outlet aperture of the microfluidic substrate.

First claim

What is claimed is:

1. An apparatus, comprising:
A portable cartridge including a first housing portion detachably coupled to a second housing portion, the first housing portion including a microfluidic substrate with a channel for transporting an eluent and an outlet aperture for emitting the eluent, the second housing portion having a plurality of spray units, each spray unit having an inlet for receiving the eluent, a lumen through which the eluent travels, and an outlet for emitting a spray of the eluent, the inlet of one of the spray units housed within the second housing portion being in fluidic communication with the outlet aperture of the microfluidic substrate, wherein the spray unit that is in fluidic communication with the outlet aperture of the microfluidic substrate extends from the second housing portion while each other spray unit is retracted within the second housing portion and is available as a spare spray unit.

2. The apparatus of claim 1 , wherein the microfluidic substrate includes a second channel for transporting an eluent and a second outlet aperture for emitting the eluent transported by the second channel, and wherein a second one of the spray units housed within the second housing portion is in fluidic communication with the second outlet aperture of the microfluidic substrate.

3. The apparatus of claim 1 , wherein the inlets of the spray units are at a coupling end of the second housing portion such that the inlet of the first spray unit becomes oriented for fluidic communication with the outlet aperture of the microfluidic substrate when the second housing portion couples to the first housing portion in a first orientation and the inlet of a second spray unit becomes oriented for fluidic communication with the outlet aperture of the microfluidic substrate when the second housing portion couples to the first housing portion in a second orientation.

4. The apparatus of claim 3 , wherein the microfluidic substrate has an edge that faces the second housing portion, the outlet aperture being on the edge of the microfluidic substrate at a location offset from a midpoint along the edge.

5. The apparatus of claim 3 , wherein the microfluidic substrate has an edge that faces the second housing portion, the outlet aperture being on the edge of the microfluidic substrate at a midpoint along the edge.

6. The apparatus of claim 3 , wherein the inlets of the plurality of spray units are oriented linearly at the coupling end of the second housing portion.

7. The apparatus of claim 3 , wherein the inlets of the plurality of spray units present a polygonal pattern at the coupling end of the second housing portion.

8. The apparatus of claim 1 , wherein the lumen of the first spray unit coupled to the outlet aperture extends generally orthogonally from the inlet of the first spray unit.

9. The apparatus of claim 1 , wherein the second housing portion is a rotary device and the outlets of the spray units extend radially from a circumferential edge of the rotary device.

10. The apparatus of claim 1 , further comprising mechanical means for automated changing which one of the spray units is presently coupled to the outlet aperture of the microfluidic substrate.

11. An apparatus comprising:
a portable housing adapted to detachably couple to a cartridge containing a microfluidic substrate; and
a plurality of microfluidic emitters disposed within the portable housing, each microfluidic emitter having an inlet for receiving a liquid and an outlet for emitting a spray, each microfluidic emitter being movable within the portable housing between a first position in which the outlet of that microfluidic emitter is fully retracted within the portable housing and a second position in which the outlet of that microfluidic emitter projects out of the portable housing in response to the portable housing being coupled to the cartridge with the microfluidic substrate.

12. The apparatus of claim 11 , wherein the inlets of the plurality of emitters are oriented linearly at a coupling end of the portable housing.

13. The apparatus of claim 11 , wherein the inlets of the plurality of emitters present a polygonal pattern at a coupling end of the portable housing.

14. The apparatus of claim 11 , wherein a lumen of each emitter extends generally orthogonally from the inlet of that emitter.

15. The apparatus of claim 11 , wherein the portable housing is a rotary device and the outlets of the emitters extend radially from a circumferential edge of the rotary device.

Assignees

• Murphy James P
• Michienzi Joseph
• Waters Technologies Corp

Inventors

• Murphy James P
• Michienzi Joseph

Classifications

• H01J49/0431 Primary

  for liquid samples (interfaces to liquid chromatographs G01N30/7233) · CPC title

• G01N30/6091

  Cartridges · CPC title

• H01J49/167

  Capillaries and nozzles specially adapted therefor; (electrostatic spraying per se B05B5/00) · CPC title

• B01L3/50273

  characterised by the means or forces applied to move the fluids · CPC title

• B01L2200/0631

  Purification arrangements, e.g. solid phase extraction [SPE] · CPC title