Compositions comprising extracts or materials derived from palm oil vegetation liquor for inhibition of vision loss due to angiogenesis and method of preparation there

Patent metadata

Field	Value
Publication number	US-2017274035-A1
Application number	US-201715488874-A
Country	US
Kind code	A1
Filing date	Apr 17, 2017
Priority date	May 18, 2011
Publication date	Sep 28, 2017
Grant date	—

Abstract

The present invention relates generally to a composition comprising palm fruit juice for use in a method of preventing and inhibiting vision loss due to angiogenesis related diseases. The composition of the present invention aids to decrease in CNV size using confocal microscopy, in addition to reduction in macrophage infiltration using immune staining; decrease in VEGF-A-induced angiogenesis using established cornea pocket assay, inhibition of IKB-D phosphorylation in laser treated choroidal tissues and reduction in macrophage recruitment to CNV lesions.

First claim

1 - 25 . (canceled)

26 . A method for treating vision loss due to an angiogenesis associated disease and VEGF receptor phosphorylation, said method comprising administering to a patient in need thereof an effective amount of an extract derived from palm oil vegetation liquor, wherein the extract is palm fruit juice.

27 . The method of claim 26 , wherein the angiogenesis related disease is associated with macular degeneration.

28 . The method of claim 26 , wherein the disease is age-related macular degeneration (AMD).

29 . The method of claim 26 , wherein the effective amount of the extract provides protective effects against glaucoma, diseases associated with glaucoma, or corneal transplants.

30 . The method of claim 26 , wherein the effective amount of the extract provides protective effects against diabetic retinopathy and diseases associated thereto.

31 . The method of claim 26 wherein the extract is a water soluble component derived from palm oil vegetation liquor.

32 . The method of claim 26 wherein the extract contains phenolics.

33 . The method of claim 26 , wherein the angiogenesis associated disease is an ocular angiogenesis associated disease.

34 . The method of claim 28 , wherein the effective amount of the extract reduces the size of choroidal neovascularization (CNV) lesions in AMD.

35 . The method of claim 28 , wherein the effective amount of the extract reduces macrophage infiltration in AMD.

36 . The method of claim 26 , wherein the effective amount of the extract suppresses VEGF-A-induced angiogenesis.

37 . The method of claim 28 , wherein the effective amount of the extract suppresses pro-inflammatory signaling in AMD.

38 . The method of claim 26 , wherein the effective amount of the extract inhibits IKB-α phosphorylation in choroidal tissues.

39 . The method of claim 28 , wherein the effective amount of the extract reduces macrophage recruitment to CNV lesions in AMD.

40 . The method of claim 26 , wherein the effective amount of the extract inhibits vision loss due to ocular neovascularization.

Assignees

• Malaysian Palm Oil Board

Inventors

• Sambanthamurthi Ravigadevi
• Tan Yew Ai
• Hafezi-Moghadam Ali

Classifications

• A23L2/02

  containing fruit or vegetable juices · CPC title

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A61K36/889 Primary

  Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto · CPC title