Use of an organic citrus extract with high antimicrobial capacity and xylitol as a preservative system in liquids, emulsions, suspensions, creams and antacids

Patent metadata

Field	Value
Publication number	US-2016346341-A1
Application number	US-201615165275-A
Country	US
Kind code	A1
Filing date	May 26, 2016
Priority date	May 29, 2015
Publication date	Dec 1, 2016
Grant date	—

Abstract

Liquid antacid compositions containing citrus extract are disclosed. The liquid antacid compositions possess superior resistance to microbial attack.

First claim

1 . A liquid antacid composition comprising:
a) an antacid; b) a citrus extract; c) xylitol; and d) optionally, one or more other pharmaceutically acceptable excipients; in an aqueous vehicle.

2 . The liquid antacid composition of claim 1 , wherein said antacid is selected from the group consisting of aluminum hydroxide; calcium hydroxide; magnesium hydroxide, sodium bicarbonate, and magnesium oxide.

3 . The liquid antacid composition of claim 1 , wherein the pH of the composition is about 7 to about 9.

4 . The liquid antacid composition of claim 2 , wherein the antacid is magnesium hydroxide.

5 . The liquid antacid composition of claim 2 , wherein the antacid is aluminum hydroxide.

6 . A method for neutralizing excess stomach acid in a human or lower animal, comprising orally administering to said human or lower animal an effective amount of the liquid antacid composition of claim 1 .

7 . A method for the treatment of a gastrointestinal disorder in a human or lower animal, comprising administering to said human or lower animal an effective amount of the liquid antacid composition of claim 1 .

8 . The method of claim 7 wherein the gastrointestinal disorder is selected from the group consisting of acid indigestion, heartburn, dyspepsia, sour stomach, reflux esophagitis, hiatal hernia and flatulence symptoms.

9 . The liquid antacid composition of claim 1 , further comprising a preservative selected from the group consisting of butylparaben, methylparaben and propylparaben.

10 . The liquid antacid composition of claim 1 , further comprising a pharmaceutically effective amount of a histamine H2 receptor antagonist.

11 . The liquid antacid composition of claim 10 , wherein the histamine H2 receptor antagonist is selected from the group consisting of cimetidine, ranitidine, nizatidine and famotidine.

12 . The liquid antacid composition of claim 1 , further comprising sorbitol.

13 . The liquid antacid composition of claim 1 , further comprising simethicone.

Assignees

• Johnson & Johnson Consumer Inc

Inventors

• Barraza Javier
• Muniz Renata

Classifications

• A61K33/06

  Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay} · CPC title

• A61P1/04

  for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants · CPC title

• A61K31/045

  Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates · CPC title

• A61P1/14

  Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents · CPC title

• A61K36/752 Primary

  Citrus, e.g. lime, orange or lemon · CPC title