Compositions and methods for modulating hair growth

Patent metadata

Field	Value
Publication number	US-12559490-B2
Application number	US-202118013803-A
Country	US
Kind code	B2
Filing date	Jun 29, 2021
Priority date	Jun 30, 2020
Publication date	Feb 24, 2026
Grant date	Feb 24, 2026

Abstract

The present disclosure relates to novel compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.

First claim

The invention claimed is:

1 . A compound represented by a formula:

or a pharmaceutically acceptable salt thereof;
wherein R 1 is -, —S(═O) 2 —, an optionally substituted C 1-12 hydrocarbon group or an optionally substituted heterocycle;
R 2 is H, an optionally substituted C 1-6 alkyl, an optionally substituted carbocycle, or an optionally substituted heterocycle;

 and
R 6 is:

2 . The compound of claim 1 , wherein R 6 is:

3 . The compound of claim 1 , wherein R 1 is -, —CH 2 —, an optionally substituted C 3-12 hydrocarbon group, or an optionally substituted heterocycle having a carbon atom directly attached to the O atom.

4 . The compound of claim 1 , wherein R 1 is an optionally substituted C 1-12 alkyl.

5 . The compound of claim 1 , wherein R 1 is an optionally substituted heterocycle.

6 . The compound of claim 1 , wherein R 1 is an optionally substituted aryl.

7 . The compound of claim 1 , wherein R 1 is an optionally substituted benzyl.

8 . The compound of claim 1 , wherein R 1 is an optionally substituted oxetane, optionally substituted dihydrofuran, optionally substituted furan, optionally substituted furanone, optionally substituted tetrahydropyran, optionally substituted dihydropyran, optionally substituted pyran, optionally substituted tetrahydropyrone, optionally substituted dihydropyrone, optionally substituted thietane, optionally substituted tetrahydrothiophene, optionally substituted dihydrothiophene, optionally substituted thiophene, optionally substituted azetidine, optionally substituted pyrrolidine, optionally substituted pyrroline, optionally substituted pyrrole, optionally substituted piperidine, optionally substituted pyridine, optionally substituted oxazole, optionally substituted isoxazole, optionally substituted thiazole, optionally substituted isothiazole, optionally substituted pyrazolidine, optionally substituted imidazolidine, optionally substituted pyrazole, optionally substituted imidazole, optionally substituted tetrazole, or optionally substituted sulfolane.

9 . The compound of claim 1 , wherein Y is -.

10 . The compound of claim 1 , wherein Y is —O—.

11 . The compound of claim 1 , wherein Y is

12 . The compound of claim 1 , wherein Y is

13 . The compound of claim 1 , wherein Y is

14 . The compound of claim 1 , wherein R 2 is H.

15 . The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

16 . The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

17 . The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

18 . A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient.

Assignees

• Univ California
• Pelage Pharmaceuticals Inc

Inventors

• Sun Daniel L
• Jung Michael E
• Gil Daniel W

Classifications

• A61P17/14

  for baldness or alopecia · CPC title

• C07D471/04 Primary

  Ortho-condensed systems · CPC title