Compositions and methods for promoting hair growth with Mpc1 inhibitors

Patent metadata

Field	Value
Publication number	US-11213513-B2
Application number	US-201716488451-A
Country	US
Kind code	B2
Filing date	Aug 25, 2017
Priority date	Feb 24, 2017
Publication date	Jan 4, 2022
Grant date	Jan 4, 2022

Abstract

Provided herein are methods of accelerating, promoting, or restoring hair growth, comprising administering to a subject in need thereof an effective amount of a compound of formula (I). Also provided are compositions comprising the compound of formula (I).

First claim

The invention claimed is:

1. A method of accelerating, promoting, or restoring hair growth, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):

or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 , wherein administering comprises topically applying a composition comprising the compound to an affected area.

3. The method of claim 1 , wherein the subject exhibits symptoms selected from alopecia, hair loss, hair thinning, and baldness.

4. The method of claim 1 , wherein the subject exhibits symptoms selected from hair loss, hair thinning, and baldness.

5. The method of claim 1 , wherein the subject exhibits baldness.

6. The method of claim 5 , wherein the baldness is male pattern baldness or female pattern baldness.

7. The method of claim 1 , wherein the subject exhibits symptoms selected from hair loss and hair thinning.

8. The method of claim 7 , wherein the hair loss or the hair thinning is caused by anagen effluvium or telogen effluvium.

9. The method of claim 3 , wherein the alopecia is selected from juvenile alopecia, premature alopecia, senile alopecia, alopecia areata, androgenic alopecia, mechanical alopecia, and symptomatic alopecia.

10. The method of claim 1 , wherein the compound is applied to a hair follicle.

11. The method of claim 1 , wherein the compound of formula (I) is administered daily.

12. The method of claim 1 , wherein the subject is a mammal.

13. The method of claim 1 , wherein the subject is a human.

14. The method of claim 1 , wherein: administering comprises topically applying a composition comprising the compound to an affected area; the subject exhibits symptoms selected from alopecia, hair loss, hair thinning, and baldness; and the subject is human.

15. The method of claim 14 , wherein the subject exhibits symptoms of baldness.

16. The method of claim 15 , wherein the baldness is male pattern baldness or female pattern baldness.

17. The method of claim 14 , wherein the subject exhibits symptoms of alopecia.

18. The method of claim 17 , wherein the alopecia is selected from juvenile alopecia, premature alopecia, senile alopecia, alopecia areata, androgenic alopecia, mechanical alopecia, and symptomatic alopecia.

19. The method of claim 14 , wherein the subject exhibits symptoms selected from hair loss and hair thinning.

20. The method of claim 19 , wherein the hair loss or the hair thinning is caused by anagen effluvium or telogen effluvium.

Assignees

• Univ California

Inventors

• Lowry William E
• Christofk Heather R
• Flores Aimee

Classifications

• A61Q7/00

  Preparations for affecting hair growth · CPC title

• A61K31/405 Primary

  Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin · CPC title

• A61K8/492 Primary

  having condensed rings, e.g. indol · CPC title

• A61P17/14 Primary

  for baldness or alopecia · CPC title

• A61K9/107

  Emulsions {; Emulsion preconcentrates; Micelles (composition of emulsions A61K47/00)} · CPC title