Compositions and methods for modulating hair growth

Patent metadata

Field	Value
Publication number	US-11472804-B2
Application number	US-202217584091-A
Country	US
Kind code	B2
Filing date	Jan 25, 2022
Priority date	Jun 30, 2017
Publication date	Oct 18, 2022
Grant date	Oct 18, 2022

Abstract

The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.

First claim

We claim:

1. A compound, wherein the compound is

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound is

3. The compound of claim 1 , wherein the compound is a pharmaceutically acceptable salt of

Assignees

• Univ California

Inventors

• Lowry William E
• Jung Michael E
• Christofk Heather R
• Liu Xiaoguang
• Flores Aimee

Classifications

• C07C255/41

  the carbon skeleton being further substituted by carboxyl groups, other than cyano groups · CPC title

• C07D213/57

  Nitriles · CPC title

• C07D417/06

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title

• A61P17/14

  for baldness or alopecia · CPC title

• A61K31/405

  Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin · CPC title