Atmospheric pressure ionisation source

Patent metadata

Field	Value
Publication number	US-12488976-B2
Application number	US-202117998009-A
Country	US
Kind code	B2
Filing date	May 5, 2021
Priority date	May 5, 2020
Publication date	Dec 2, 2025
Grant date	Dec 2, 2025

Abstract

An atmospheric pressure ionisation source comprising: an ionisation chamber, comprising an inlet for receiving at least the distal end of a capillary into the ionisation chamber in use; a desolvation heater including a heating element, for directing a stream of heated gas onto the distal end of the capillary in use; a corona discharge device arranged in the ionisation chamber; and a control system configured to operate the source in a selected one of: an analytical mode, in which the heating element is heated to a first temperature within a first temperature range, and in which a first current within a first current range is supplied to the corona discharge device; and a capillary priming mode, in which the heating element is heated to a second temperature within a second temperature range, and in which a second current within a second current range is supplied to the corona discharge device, wherein the lower limit of the second temperature range is higher than the lower limit of the first temperature range, and the second current range is higher than the first current range.

First claim

The invention claimed is:

1 . An atmospheric pressure ionisation source comprising:
an ionisation chamber, comprising an inlet for receiving at least the distal end of a capillary into the ionisation chamber in use; a desolvation heater including a heating element, for directing a stream of heated gas onto the distal end of the capillary in use; a corona discharge device arranged in the ionisation chamber; and a control system configured to operate the source in a selected one of: an analytical mode, in which the ionisation chamber is configured to receive at least the distal end of the capillary with the addition of a sample, wherein the heating element is heated to a first temperature within a first temperature range, and in which a first current within a first current range is supplied to the corona discharge device; and a capillary priming mode, in which the ionisation chamber is configured to receive at least the distal end of the capillary prior to the addition of a sample, wherein the heating element is heated to a second temperature within a second temperature range, and in which a second current within a second current range is supplied to the corona discharge device, wherein the lower limit of the second temperature range is higher than the lower limit of the first temperature range, and the second current range is higher than the first current range.

2 . An atmospheric pressure ionisation source according to claim 1 , wherein the first temperature range is an analytical temperature range.

3 . An atmospheric pressure ionisation source according to claim 1 , wherein the first temperature range is between 50° C. and 600° C.

4 . An atmospheric pressure ionisation source according to claim 1 , wherein the first temperature is between 350° C. and 450° C.

5 . An atmospheric pressure ionisation source according to claim 1 , wherein the upper limit of the first temperature range is substantially the same as the upper limit of the second temperature range.

6 . An atmospheric pressure ionisation source according to claim 1 , wherein the second temperature range is configured so as to substantially clean the distal end of a capillary placed within the stream of heated gas in use.

7 . An atmospheric pressure ionisation source according to claim 1 , wherein the upper limit of the second temperature range is the maximum temperature of the heating element.

8 . An atmospheric pressure ionisation source according to claim 1 , wherein the second temperature range is between 550° C. and 600° C.

9 . An atmospheric pressure ionisation source according to claim 1 , wherein the second temperature is substantially equal to the upper limit of the second temperature range.

10 . An atmospheric pressure ionisation source according to claim 1 , wherein the first current range is an analytical current range.

11 . An atmospheric pressure ionisation source according to claim 1 , wherein the first current range is within 2 and 4 μA.

12 . An atmospheric pressure ionisation source according to claim 11 , wherein the first current is substantially 3 μA.

13 . An atmospheric pressure ionisation source according to claim 1 , wherein the second current range is the maximum current deliverable to the corona discharge device.

14 . An atmospheric pressure ionisation source according to claim 1 , wherein the second current range is 8 to 50 μA.

15 . An atmospheric pressure ionisation source according to claim 14 , wherein in the capillary priming mode the corona discharge device is operated in a positive ionisation mode and the second current is 10 μA.

16 . An atmospheric pressure ionisation source according to claim 14 , wherein in the capillary priming mode the corona discharge device is operated in a negative ionisation mode and the second current is 8 μA.

17 . An atmospheric pressure ionisation source according to claim 1 , wherein the desolvation heater further comprises a gas source, and the desolvation heater is configured to direct gas from the gas source over the heating element, thereby heating the gas.

18 . An atmospheric pressure ionisation source according to claim 1 , wherein the desolvation heater is configured to output a stream of heated gas at a first flow rate within a first flow rate range during the analytical mode; and to output a stream of heated gas at a second flow rate within a second flow rate range during the capillary priming mode.

19 . An atmospheric pressure ionisation source according to claim 18 , wherein the first flow rate range is between 2 and 3 litres per minute.

20 . An atmospheric pressure ionisation source according to claim 18 , wherein the second flow rate range is between 18 and 22 litres per minute.

Assignees

• Micromass Ltd

Inventors

• Lumley Nicola
• Douce David
• Jones Gareth Rhys

Classifications

• H01J49/168

  field ionisation, e.g. corona discharge (atmospheric pressure corona discharge per se H01T19/00) · CPC title

• H01J49/0404 Primary

  Capillaries used for transferring samples or ions (electrospray nozzles H01J49/167) · CPC title

• H01J49/16

  using surface ionisation, e.g. field-, thermionic- or photo-emission · CPC title

• H01J49/04

  Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components · CPC title

• H01J49/0477 Primary

  using a hot fluid · CPC title