Direct sample analysis device adapters and methods of using them

Patent metadata

Field	Value
Publication number	US-9117641-B2
Application number	US-201213662745-A
Country	US
Kind code	B2
Filing date	Oct 29, 2012
Priority date	Oct 29, 2012
Publication date	Aug 25, 2015
Grant date	Aug 25, 2015

Abstract

Certain embodiments described herein are directed to adapters for use in coupling a direct sample analysis device to an analytical instrument such as, for example, a mass spectrometer. In some examples, the adapter can include an internal coupler separated from an external coupler through an insulator.

First claim

The invention claimed is:

1. An adapter for installing a direct sample analysis device on a mass spectrometer, the adapter comprising:
a capillary sleeve configured to couple to a capillary inlet of the mass spectrometer, in which the capillary sleeve is configured to couple to the capillary inlet through a friction fit between outer surfaces of the capillary inlet and inner surfaces of the capillary sleeve; and
an end cap extension configured to couple to the capillary sleeve, in which the capillary sleeve and end cap extension are configured to provide fluidic coupling between a sample holder of the direct sample analysis device and the mass spectrometer through the capillary inlet.

2. The adapter of claim 1 , in which the end cap extension is configured to couple to a lens assembly.

3. The adapter of claim 2 , in which the lens assembly is configured to slidingly engage to the end cap extension.

4. The adapter of claim 1 , in which the end cap extension is configured to slidingly engage to the capillary sleeve.

5. The adapter of claim 1 , in which the capillary sleeve comprises arms that engage outer surfaces of the capillary inlet.

6. The adapter of claim 5 , in which the end cap extension couples to the capillary sleeve through a friction fit.

7. The adapter of claim 1 , in which the capillary sleeve comprises an insulator configured to electrically decouple the capillary sleeve from the end cap extension.

8. The adapter of claim 7 , in which the capillary sleeve is further configured to center the capillary inlet.

9. The adapter of claim 1 , in which the end cap extension comprises an insulator configured to electrically decouple the capillary sleeve from the end cap extension.

10. The adapter of claim 9 , in which the end cap extension is further configured to center the capillary inlet.

11. The adapter of claim 1 , in which the capillary sleeve and the end cap together are configured to permit coupling of a direct sampling analysis device to the mass spectrometer without removal of a source block of the mass spectrometer.

12. The adapter of claim 1 , in which the capillary sleeve and the end cap together are configured to permit coupling of a direct sampling analysis device to the mass spectrometer without removal of any lenses of the mass spectrometer.

13. An adapter for installing a direct sample analysis device on a mass spectrometer, the adapter comprising an internal sleeve configured to couple to a capillary inlet of the mass spectrometer through a friction fit between inner surfaces of the internal sleeve and outer surfaces of the capillary inlet, an external sleeve coupled to the internal capillary sleeve, and an insulator between the internal sleeve and the external sleeve to electrically decouple the internal sleeve from the external sleeve, in which the adapter is configured to provide fluidic coupling between a sample holder of the direct sample analysis device and the mass spectrometer through the capillary inlet.

14. The adapter of claim 13 , in which the external sleeve is configured to couple to a lens assembly.

15. The adapter of claim 14 , in which the lens assembly is configured to slidingly engage to the external sleeve.

16. The adapter of claim 13 , in which the external sleeve is configured to slidingly engage to the internal sleeve.

17. The adapter of claim 13 , in which the internal sleeve comprises arms that engage outer surfaces of the capillary inlet.

18. The adapter of claim 17 , in which the external sleeve couples to the internal sleeve through a friction fit.

19. The adapter of claim 13 , in which the internal sleeve is sized and arranged to center the capillary inlet in the internal sleeve.

20. The adapter of claim 13 , in which the insulator comprises at least one ceramic material.

21. The adapter of claim 13 , in which the adapter is configured to permit coupling of the direct sample analysis device while maintaining a vacuum of the mass spectrometer.

22. The adapter of claim 13 , in which the adapter is configured to permit coupling of the direct sample analysis device without removing any lenses of the mass spectrometer.

23. The adapter of claim 13 , in which the inner sleeve and the external sleeve together are configured to permit coupling of a direct sampling analysis device to the mass spectrometer without removal of a source block of the mass spectrometer.

24. The adapter of claim 13 , in which the inner sleeve and the external sleeve together are configured to permit coupling of a direct sampling analysis device to the mass spectrometer without removal of any lenses of the mass spectrometer.

Assignees

• St Cyr Paul L
• Delvecchio Michael L
• Whitehouse Craig M
• Perkinelmer Health Sci Inc

Inventors

• St Cyr Paul L
• Delvecchio Michael L
• Whitehouse Craig M

Classifications

• H01J49/0404 Primary

  Capillaries used for transferring samples or ions (electrospray nozzles H01J49/167) · CPC title