Apparatus and methods for preparation and introduction of trace samples into an ionizing detection system

Patent metadata

Field	Value
Publication number	US-12399152-B2
Application number	US-202217715287-A
Country	US
Kind code	B2
Filing date	Apr 7, 2022
Priority date	Mar 11, 2019
Publication date	Aug 26, 2025
Grant date	Aug 26, 2025

Abstract

The present disclosure describes an improved sample preparation technique, swab, swab holder and solvent for the removal of trace chemical materials from swabs and delivery of the trace materials into a mass spectrometer (MS) or an ion mobility spectrometer (IMS). The devices and techniques aid the delivery of the analyte into the instrument inlet and concurrently serves as an ionization source. The technique includes the steps of positioning or shaping the swab so that a pointed analyte release area is directed toward the inlet of the MS or IMS, adding a solvent to the swab and charging the swab to create an ionized analyte spray (Taylor Cone spray) into the inlet of the detection instrument. Solvent may include a chemical for depressing the ionization of residual solvent or enhancing the ionization of the desired analyte and this chemical may serve as an internal standard or benchmark.

First claim

What is claimed:

1. Apparatus for chemical trace detection comprising:
a spectrometry testing instrument comprising,
an inlet port configured to receive a vaporized analyte, and
a detector configured to analyze the vaporized analyte;

a swab having a distal end with an analyte release area, said analyte release area having an apex angle of 120 degrees or less; and
a swab holder comprising,
a housing configured to be mounted in front of the inlet port of said spectrometry testing instrument, said housing having a swab positioning slot configured to slidably receive said swab and position said swab with said analyte release area adjacent to and directed toward the inlet; and

a high voltage electrical source having
a ground in electrical communication with the inlet port; and
a delivery contact within said housing and having a terminal contact end engaging said swab when received within said swab positioning slot,
whereby voltage is selectively applied to an analyte of a chemical sample on said swab and directs an ionized plume of said analyte into said inlet port, and

wherein the high voltage electrical source is configured and arranged to apply said voltage such that there is a differential potential between said swab and said inlet port.

2. The apparatus of claim 1 wherein said apex angle is 45 degrees or less.

3. The apparatus of claim 1 wherein said spectrometry testing instrument is an IMS device or an MS device.

4. The apparatus of claim 1 wherein said terminal contact end engages said analyte release area when received within said swab positioning slot.

5. The apparatus of claim 1 further comprising a solvent.

6. The apparatus of claim 5 wherein said solvent includes an internal standard or an adducting agent.

7. The apparatus of claim 6 further comprising a solvent dispenser comprising a solvent supply container, a solvent dispenser nozzle positioned adjacent to said analyte release area and a pump in fluid communication with said solvent supply container and said solvent dispenser nozzle and selectively actuable to dispense a predetermined volume of solvent from said solvent supply container through said dispensing nozzle and onto said analyte release area.

8. The apparatus of claim 7 wherein said solvent dispenser is mounted to said housing of said swab holder.

9. The apparatus of claim 6 wherein said spectrometry testing instrument is an IMS device or an MS device.

10. The apparatus of claim 1 wherein said swab has a sampling end including a central preformed triangular analyte release area and flanking side portions.

11. The apparatus of claim 10 , wherein said housing includes deflector arms which deflect the flanking side portions of said sampling end of said swab away from the analyte release area.

12. Apparatus for chemical trace detection comprising:
a swab having a distal end with an analyte release area, said analyte release area having an apex angle of 120 degrees or less; and
a swab holder comprising,
a housing including a swab positioning slot configured to slidably receive said swab and position said swab with said analyte release area adjacent to and directed toward an inlet port of a spectrometry testing instrument; and

a high voltage electrical source having
a ground in electrical communication with the inlet port; and
a voltage delivery contact within said housing and having a terminal contact end engaging said swab when received within said swab positioning slot,
whereby voltage is selectively applied to an analyte of a chemical sample on said swab and directs an ionized plume of said analyte into said inlet port, and

wherein the high voltage electrical source is configured and arranged to apply said voltage such that there is a differential potential between said swab and said inlet port.

13. The apparatus of claim 12 wherein said apex angle is 45 degrees or less.

14. The apparatus of claim 12 wherein said spectrometry testing instrument is an IMS device or an MS device.

15. The apparatus of claim 12 wherein said terminal contact end engages said analyte release area when received within said swab positioning slot.

16. The apparatus of claim 12 further comprising a solvent.

17. The apparatus of claim 16 wherein said solvent includes an internal standard or adducting agent.

18. The apparatus of claim 17 further comprising a solvent dispenser comprising a solvent supply container, a solvent dispenser nozzle positioned adjacent to said analyte release area and a pump in fluid communication with said solvent supply container and said solvent dispenser nozzle and selectively actuable to dispense a predetermined volume of solvent from said solvent supply container through said dispensing nozzle and onto said analyte release area.

19. The apparatus of claim 18 wherein said solvent dispenser is mounted to said housing of said swab holder.

20. The apparatus of claim 17 wherein said spectrometry testing instrument is an IMS device or an MS device.

21. The apparatus of claim 12 wherein said swab has a sampling end including a central preformed triangular analyte release area and flanking side portions.

22. The apparatus of claim 21 , wherein said housing includes deflector arms which deflect the flanking side portions of said sampling end of said swab away from the analyte release area when said swab is received within said slot.

Assignees

• Univ Of Rhode Island Board Of Trustees

Inventors

• Oxley Jimmie
• Smith James L
• Yevdokimov Alexander

Classifications

• H01J49/26

  Mass spectrometers or separator tubes · CPC title

• H01J49/0031

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• G01N2001/022

  sampling for security purposes, e.g. contraband, warfare agents · CPC title

• H01J49/165

  Electrospray ionisation · CPC title

• H01J49/04

  Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components · CPC title