Biological equivalent dose informed flash radiation therapy

Patent metadata

Field	Value
Publication number	US-12383765-B2
Application number	US-202318207404-A
Country	US
Kind code	B2
Filing date	Jun 8, 2023
Priority date	Jun 8, 2023
Publication date	Aug 12, 2025
Grant date	Aug 12, 2025

Abstract

A control circuit accesses information representing radiation dose deposition as a function of time for a particular patient as well as at least one biological parameter for that particular patient. The control circuit then determines a biological equivalent dose for the particular patient as a function of both the information representing radiation dose deposition as a function of time and the at least one biological parameter to provide a determined biological equivalent dose for the particular patient.

First claim

What is claimed is:

1. A method comprising:
by a control circuit:
accessing information representing a radiation dose deposition as a function of time for a particular patient;
accessing at least one biological parameter for the particular patient; and
determining a biological equivalent dose for the particular patient as a function of both the information representing a radiation dose deposition as a function of time for the particular patient and the at least one biological parameter for the particular patient to provide a determined biological equivalent dose for the particular patient.

2. The method of claim 1 , wherein determining a biological equivalent dose for the particular patient comprises determining a plurality of biological equivalent doses for the particular patient as a function of both the information representing a radiation dose deposition as a function of time for the particular patient and the at least one biological parameter for the particular patient to provide a plurality of determined biological equivalent doses for the particular patient.

3. The method of claim 1 , wherein the information representing a radiation dose deposition as a function of time for the particular patient comprises both dose information and dose rate information.

4. The method of claim 1 , wherein the at least one biological parameter for the particular patient comprises normal tissue complication probability information.

5. The method of claim 1 , wherein the at least one biological parameter for the particular patient comprises oxygen level information.

6. The method of claim 1 , wherein the at least one biological parameter for the particular patient comprises linear energy transfer information.

7. The method of claim 1 , wherein the at least one biological parameter for the particular patient comprises at least one of:
an identified tissue;
an identified organ;
a specified portion of an identified organ;
a temporal-based parameter;
a radiosensitivity of a given tissue/organ;
patient image information;
a tissue type;
a blood oxygen level;
a blood type;
a medication;
chemotherapy information;
prior surgery information;
immunotherapy information;
prior medical treatment information;
demographic information;
biological age information;
genetic marker information;
a time of day;
a tumor type;
pH (potential hydrogen) balance information;
temperature information;
blood pressure information;
blood panel information; and
immunity health information.

8. The method of claim 1 , further comprising:
optimizing a FLASH radiation therapy treatment plan as a function, at least in part, of the determined biological equivalent dose for the particular patient to provide an optimized FLASH radiation therapy treatment plan.

9. The method of claim 8 , further comprising:
administering radiation to the particular patient as a function of the optimized FLASH radiation therapy treatment plan.

10. The method of claim 8 , further comprising:
quality evaluating the optimized FLASH radiation therapy treatment plan as a function, at least in part, of the determined biological equivalent dose for the particular patient.

11. The method of claim 1 , further comprising:
generating a radiation treatment prescription as a function, at least in part, of the determined biological equivalent dose for the particular patient.

12. An apparatus comprising:
a memory having stored therein information representing a radiation dose deposition as a function of time for a particular patient and at least one biological parameter for the particular patient; and
a control circuit operably coupled to the memory and configured to:
access the information representing a radiation dose deposition as a function of time for a particular patient;
access the at least one biological parameter for the particular patient; and
determine a biological equivalent dose for the particular patient as a function of both the information representing a radiation dose deposition as a function of time for the particular patient and the at least one biological parameter for the particular patient to provide a determined biological equivalent dose for the particular patient.

13. The apparatus of claim 12 , wherein the control circuit is configured to develop a biological equivalent dose for the particular patient by determining a plurality of biological equivalent doses for the particular patient as a function of both the information representing a radiation dose deposition as a function of time for the particular patient and the at least one biological parameter for the particular patient to thereby provide a plurality of determined biological equivalent doses for the particular patient.

14. The apparatus of claim 12 , wherein the information representing a radiation dose deposition as a function of time for the particular patient comprises, at least in part, dose rate information.

15. The apparatus of claim 12 , wherein the information representing a radiation dose deposition as a function of time for the particular patient comprises both dose information and dose rate information.

16. The apparatus of claim 12 , wherein the at least one biological parameter for the particular patient comprises normal tissue complication probability information.

17. The apparatus of claim 12 , wherein the at least one biological parameter for the particular patient comprises oxygen level information.

18. The apparatus of claim 12 , wherein the at least one biological parameter for the particular patient comprises linear energy transfer information.

19. The apparatus of claim 12 , wherein the at least one biological parameter for the particular patient comprises at least one of:
an identified tissue;
an identified organ;
a specified portion of an identified organ;
a temporal-based parameter;
a radiosensitivity of a given tissue/organ;
patient image information;
a tissue type;
a blood oxygen level;
a blood type;
a medication;
chemotherapy information;
prior surgery information;
immunotherapy information;
prior medical treatment information;
demographic information;
biological age information;
genetic marker information;
a time of day;
a tumor type;
pH (potential hydrogen) balance information;
temperature information;
blood pressure information;
blood panel information; and
immunity health information.

20. The apparatus of claim 12 , wherein the control circuit is further configured to:
optimize a FLASH radiation therapy treatment plan as a function, at least in part, of the determined biological equivalent dose for the particular patient to provide an optimized FLASH radiation therapy treatment plan.

21. The apparatus of claim 20 , wherein the control circuit is further configured to:
administer radiation to the particular patient as a function of the optimized FLASH radiation therapy treatment plan.

22. The apparatus of claim 20 , wherein the control circuit is further configured to:
quality evaluate the optimized FLASH radiation therapy treatment plan as a function, at least in part, of the determined biological equivalent dose for the particular patient.

23. The apparatus of claim 12 , wherein the control circuit is further configured to:
generate a radiation treatment prescription as a function, at least in part, of the determined biological equivalent dose for the particular patient.

Assignees

• Siemens Healthineers Int Ag

Inventors

• Lansonneur Pierre
• Folkerts Michael
• Krieger Miriam

Classifications

• A61N5/1081

  Rotating beam systems with a specific mechanical construction, e.g. gantries · CPC title

• A61N5/1045

  using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT · CPC title

• A61N5/1047

  with movement of the radiation head during application of radiation, e.g. for intensity modulated arc therapy or IMAT · CPC title

• A61N2005/1074

  Details of the control system, e.g. user interfaces · CPC title

• A61N2005/1089

  Electrons · CPC title