Apparatus and method pertaining to determining a spatially-variant normal tissue constraint as a function of dose distribution

Patent metadata

Field	Value
Publication number	US-9387345-B2
Application number	US-201213548590-A
Country	US
Kind code	B2
Filing date	Jul 13, 2012
Priority date	Jul 13, 2012
Publication date	Jul 12, 2016
Grant date	Jul 12, 2016

Abstract

A control circuit optimizes a radiation-treatment plan (as regards treating at least one target volume for a given patient) by automatically determining a spatially-variant normal tissue constraint as a function, at least in part, of dose distribution for normal tissue that is proximal to the target volume. If desired, the control circuit can repeatedly determine spatially-variant normal tissue constraints while optimizing the radiation-treatment plan. This automatic determination can comprise evaluating dose distributions at specific different distances from the target volume. So configured, the control circuit can effect such evaluation by penalizing, during the optimization of the radiation-treatment plan, dose distribution levels that exceed a predetermined distribution property (such as an aggregation value for the dose values including, but not limited to, an average value of dose values for each of the given specific different distances) at a given one of the specific different distances.

First claim

We claim:

1. An apparatus comprising:
a control circuit configured to optimize a radiation-treatment plan to treat at least one target volume for a given patient by, at least in part:
automatically determining a spatially-variant normal tissue constraint as a function, at least in part, of dose distribution.

2. The apparatus of claim 1 wherein the dose distribution constitutes dose distribution for other than the at least one target volume.

3. The apparatus of claim 2 wherein the dose distribution comprises dose distribution for normal tissue proximal to the at least one target volume.

4. The apparatus of claim 1 wherein the control circuit is configured to automatically determine the spatially-variant normal tissue constraint as a function, at least in part, of dose distribution by, at least in part, evaluating dose distributions at specific different distances from at least one target volume.

5. The apparatus of claim 4 wherein the control circuit is configured to evaluate the dose distributions at specific different distances from the at least one target volume by, at least in part, penalizing, during the optimization of the radiation-treatment plan, dose distribution levels that exceed a predetermined distribution property at a given one of the specific different distances.

6. The apparatus of claim 5 wherein the predetermined distribution property for a given one of the specific different distances comprises an aggregation value of dose values for a given one of the specific different distances.

7. The apparatus of claim 6 wherein the aggregation value comprises an average value of dose values for the given one of the specific different distances.

8. The apparatus of claim 7 wherein the aggregation value comprises the average value as weighted by a predetermined constant.

9. The apparatus of claim 1 wherein the control circuit is configured to automatically determine the spatially-variant normal tissue constraint by repeatedly determining spatially-variant normal tissue constraints while optimizing the radiation-treatment plan.

10. A method comprising:
by a control circuit configured to optimize a radiation-treatment plan to treat at least one target volume for a given patient:
automatically determining a spatially-variant normal tissue constraint as a function, at least in part, of dose distribution.

11. The method of claim 10 wherein the dose distribution constitutes dose distribution for other than the at least one target volume.

12. The method of claim 11 wherein the dose distribution comprises dose distribution for normal tissue proximal to the at least one target volume.

13. The method of claim 10 wherein automatically determining the spatially-variant normal tissue constraint as a function, at least in part, of dose distribution comprises, at least in part, evaluating dose distributions at specific different distances from at least one target volume.

14. The method of claim 13 wherein evaluating the dose distributions at specific different distances from the at least one target volume comprises, at least in part, penalizing, during the optimization of the radiation-treatment plan, dose distribution levels that exceed a predetermined distribution property at a given one of the specific different distances.

15. The method of claim 14 wherein the predetermined distribution property for a given one of the specific different distances comprises an aggregation value of dose values for a given one of the specific different distances.

16. The method of claim 15 wherein the aggregation value comprises an average value of dose values for the given one of the specific different distances.

17. The method of claim 16 wherein the aggregation value comprises the average value as weighted by a predetermined constant.

18. The method of claim 10 wherein automatically determining the spatially-variant normal tissue constraint comprises repeatedly determining spatially-variant normal tissue constraints while optimizing the radiation-treatment plan.

Assignees

• Nord Janne
• Peltola Jarkko
• Varian Medical Systems Int Ag

Inventors

• Nord Janne
• Peltola Jarkko

Classifications

• A61N5/1031 Primary

  using a specific method of dose optimization · CPC title

• A61N2005/1041

  using a library of previously administered radiation treatment applied to other patients · CPC title