System and method for determining amount of radioactive material to administer to a patient

Patent metadata

Field	Value
Publication number	US-2016287903-A1
Application number	US-201615132590-A
Country	US
Kind code	A1
Filing date	Apr 19, 2016
Priority date	Nov 21, 2006
Publication date	Oct 6, 2016
Grant date	—

Abstract

A computerized system and method are provided for determining an optimum amount of radioactivity to administer to a patient, comprising: assuming an activity retention limit; utilizing the activity retention limit to determine a dose rate for a phantom category; utilizing the dose rate for the phantom category to determine the dose rate for a second phantom category; and utilizing the dose rate for a second phantom category to find information regarding the second phantom category. In other embodiments, a computerized system and method are provided for determining an optimum amount of radioactivity to administer to a patient, comprising: obtaining at least one image relating to anatomy of a particular patient; obtaining multiple images regarding radioactivity distribution over time in the particular patient; combining the radioactivity images with the anatomy images; running a Monte Carlo simulation to obtain dose image information; and using the dose image information to obtain BED and/or EUD information.

First claim

What is claimed is:

1 . A computerized method for determining an optimum amount of radioactivity to administer to a patient, comprising:
assuming an activity retention limit; utilizing the activity retention limit to determine a dose rate for a phantom category; utilizing the dose rate for the phantom category to determine the dose rate for a second phantom category; and utilizing the dose rate for a second phantom category to find information regarding the second phantom category.

2 . The method of claim 1 , wherein the information is the activity retention limit for the second phantom category.

3 . The method of claim 1 , further comprising:
obtaining the mean absorbed dose by integrating the dose rate over time; using the mean absorbed dose to determine an optimum amount of radioactivity to administer to the patient.

4 . The method of claim 1 , wherein a dose rate resulting from short range particulate emissions is distinguished from a dose rate resulting from longer range emissions.

5 . The method of claim 4 , wherein the short range particulate emissions are electrons.

6 . The method of claim 4 , wherein the longer range emissions are photons.

7 . The method of claim 1 , wherein utilizing the activity retention limit to determine the dose rate for the phantom category further comprises calculating how the dose rate is related to the activity retention limit in a particular point in time.

8 . The method of claim 1 , wherein utilizing the activity retention limit to determine the dose rate for the phantom category further comprises using the following formula:
DR P ( t )= A LU ( t )· S LU←LU P +A RB ( t )· S LU←RB P   (1),

with:

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Assignees

• Univ Johns Hopkins

Inventors

• Sgouros George
• Song Hong
• Prideaux Andrew
• Hobbs Robert

Classifications

• A61B6/032

  Transmission computed tomography [CT] · CPC title

• A61B6/037

  Emission tomography · CPC title

• A61N2005/1089

  Electrons · CPC title

• A61B6/5217

  extracting a diagnostic or physiological parameter from medical diagnostic data · CPC title

• A61N5/1031 Primary

  using a specific method of dose optimization · CPC title