Toll like receptor modulator compounds

Patent metadata

Field	Value
Publication number	US-12377100-B2
Application number	US-202117540563-A
Country	US
Kind code	B2
Filing date	Dec 2, 2021
Priority date	Mar 4, 2015
Publication date	Aug 5, 2025
Grant date	Aug 5, 2025

Abstract

The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.

First claim

We claim:

1. A compound, or a pharmaceutically acceptable salt thereof, of Formula (IVa)

R 1 is hydrogen;
R 2 is hydrogen, methyl, fluoro or chloro;
R 3 is hydrogen or methyl; and
the moiety

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein:
R 1 is hydrogen;
R 2 is hydrogen or fluoro; and
R 3 is hydrogen or methyl.

3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein:
R 1 is hydrogen;
R 2 is hydrogen or fluoro; and
R 3 is hydrogen.

4. The compound of claim 1 , selected from

or a pharmaceutically acceptable salt thereof.

5. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

Assignees

• Gilead Sciences Inc

Inventors

• Aktoudianakis Evangelos
• Chin Gregory
• Mackman Richard L
• Metobo Samuel E
• Mish Michael R
• Pyun Hyung-Jung
• Zablocki Jeff

Classifications

• C07D401/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• C07D239/84

  Nitrogen atoms · CPC title

• C07D471/04 Primary

  Ortho-condensed systems · CPC title

• A61K2300/00

  Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title