4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US-9259426-B2 · Feb 16, 2016 · US
US10285990B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10285990-B2 |
| Application number | US-201715496283-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 25, 2017 |
| Priority date | Mar 4, 2015 |
| Publication date | May 14, 2019 |
| Grant date | May 14, 2019 |
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The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.
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We claim: 1. A method of treating a hepatitis B viral infection, comprising administering to an individual in need thereof a therapeutically effective amount of a compound which is or a pharmaceutically acceptable salt thereof. 2. The method of claim 1 , further comprising administering one or more additional therapeutic agents. 3. The method of claim 1 , further comprising administering tenofovir alafenamide, tenofovir alafenamide fumarate, or tenofovir alafenamide hemifumarate. 4. A method of treating a hepatitis B viral infection, comprising administering to an individual in need thereof a therapeutically effective amount of a compound which is 5. The method of claim 4 , further comprising administering one or more additional therapeutic agents. 6. The method of claim 4 , further comprising administering tenofovir alafenamide, tenofovir alafenamide fumarate, or tenofovir alafenamide hemifumarate.
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