Embolic compositions

Patent metadata

Field	Value
Publication number	US-12376863-B2
Application number	US-202418587736-A
Country	US
Kind code	B2
Filing date	Feb 26, 2024
Priority date	Aug 26, 2016
Publication date	Aug 5, 2025
Grant date	Aug 5, 2025

Abstract

Described herein are compositions comprising, a polymer, a non-physiological solution; and a visualization agent; wherein the polymer is soluble in the non-physiological solution and insoluble at physiological conditions. Methods of preparing the compositions are disclosed as well as methods of using these compositions to treat vascular conditions.

First claim

We claim:

1. A method of treating a vascular condition comprising:
administering a composition by injection into a vessel;
wherein the vessel is at physiological conditions;
wherein the composition includes a biocompatible polymer, a solvent, and a visualization agent;
wherein the biocompatible polymer is soluble in the solvent and insoluble at physiological conditions; and
wherein the composition has a viscosity less than or equal to 15 centistokes.

2. The method of claim 1 , wherein the visualization agent is integrated into or associated with the biocompatible polymer.

3. The method of claim 2 , wherein the visualization agent is triiodophenol-lactide-glycolide (TIP).

4. The method of claim 1 , wherein physiological conditions include contact with a physiological fluid including blood, urine, saliva, mucous, vaginal fluid, seminal fluid, cerebral spinal fluid, sweat, plasma, bile, stomach acid, intestinal fluids, or a combination thereof.

5. The method of claim 4 , wherein the physiological fluid has a pH of about 7.0.

6. The method of claim 4 , wherein the physiological fluid has a pH of between about 7.0 and about 7.8.

7. The method of claim 1 , wherein the solvent is a water miscible organic solvent.

8. The method of claim 1 , wherein the biocompatible polymer comprises an amine and the amine includes an amino group which is about 90% positively charged at pH 5 and about 10% positively charged at pH 7.

9. The method of claim 1 , wherein the biocompatible polymer includes hydroxyethylmethacrylate (HEMA), lactide, glycolide, polyvinyl pyridine (PVP), 1-vinylimidazole, aminoethyl methacrylate (AEMA), 4-vinylpyridine, alkylalkylacrylate, alkylacrylate, acrylate, styrene, polyvinyl alcohol (PVA), acrylamide, ethylene glycol, or combinations thereof.

10. The method of claim 1 , wherein the biocompatible polymer includes about 60% w/w HEMA and the visualization agent includes about 40% w/w TIP.

11. The method of claim 1 , wherein the biocompatible polymer includes about 15% w/w HEMA and the visualization agent includes about 85% w/w TIP.

12. The method of claim 1 , wherein the solvent is water or a co-solvent of water and dimethyl sulfoxide (DMSO).

13. The method of claim 1 , further comprising aminopropylmethacrylamide.

14. The method of claim 13 , wherein the composition has a viscosity of less than about 14 centistokes.

15. The method of claim 1 , wherein the composition has a viscosity of less than about 14 centistokes.

16. The method of claim 1 , wherein the biocompatible polymer, together with the visualization agent, forms a cohesive precipitate when insoluble at physiological conditions, and wherein the cohesive precipitate is more cohesive than a precipitate formed from an embolic composition comprising N-butyl-2-cyanoacrylate.

17. The method of claim 1 , wherein the biocompatible polymer is formed from hydroxyethylmethacrylate monomers and aromatic amine monomers.

18. The method of claim 1 , wherein:
the biocompatible polymer comprises HEMA;
the solvent comprises a co-solvent of water and DMSO; and
the visualization agent comprises TIP.

19. The method of claim 1 , wherein the composition has a viscosity of less than about 13 centistokes.

20. The composition of claim 1 , wherein the composition has a viscosity of less than about 12 centistokes.

Assignees

• Microvention Inc

Inventors

• Baldwin Aaron
• Mehta Ami
• Lam Jonathan

Classifications

• A61K49/0442

  Polymeric X-ray contrast-enhancing agent comprising a halogenated group · CPC title

• A61K49/0438

  Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol · CPC title

• A61B2090/3966

  Radiopaque markers visible in an X-ray image · CPC title

• A61B2090/3933

  Liquid markers · CPC title

• A61B2017/00942

  hydrophilic · CPC title