Radioactive liquid embolic

Patent metadata

Field	Value
Publication number	US-10576182-B2
Application number	US-201816155763-A
Country	US
Kind code	B2
Filing date	Oct 9, 2018
Priority date	Oct 9, 2017
Publication date	Mar 3, 2020
Grant date	Mar 3, 2020

Abstract

Liquid embolic preparations and medical treatment methods of using those preparations are described. In some embodiments, the preparations or solutions can transition from a liquid to a solid for use in the embolization. The preparations can include biocompatible polymers with covalently bound radioactive iodine isotopes.

First claim

We claim:

1. A polymeric composition comprising:
a biocompatible polymer comprising a reaction product of:
a first monomer including a polymerizable moiety having a linkage to a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope, and wherein the first monomer is 2,4,6-triiodophenyl 5-(2-(2-(acryloyloxy)acetoxy)acetoxy)-2-methyl-4-oxohexanoate,
and a second monomer including a polymerizable moiety and at least one hydroxyl group; and
a non-physiological solution;
wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution.

2. The polymeric composition of claim 1 , wherein the linkage is biodegradable.

3. The polymeric composition of claim 1 , further including folic acid or a functionalized form thereof.

4. The polymeric composition of claim 1 , wherein the radioactive isotope is 123 I, 124 I, 125 I, 131 I, or a combination thereof.

5. The polymeric composition of claim 1 , wherein the radioactive isotope is 123 I.

6. The polymeric composition of claim 1 , wherein the radioactive isotope is 124 I.

7. The polymeric composition of claim 1 , wherein the radioactive isotope is 125 I.

8. The polymeric composition of claim 1 , wherein the radioactive isotope is 131 I.

9. The polymeric composition of claim 2 , further including folic acid or a functionalized form thereof.

10. A polymeric composition comprising:
biocompatible polymer particles, wherein the polymer particles include a reaction product of:
a first monomer including a polymerizable moiety having a linkage to a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope, and wherein the first monomer is 2,4,6-triiodophenyl 5-(2-(2-(acryloyloxy)acetoxy)acetoxy)-2-methyl-4-oxohexanoate,
and a second monomer including a polymerizable moiety.

11. The polymeric composition of claim 10 , wherein the linkage is biodegradable.

12. The polymeric composition of claim 10 , further including folic acid or a functionalized form thereof.

13. The polymeric composition of claim 10 , wherein the radioactive isotope is 123 I, 124 I, 125 I, 131 I, or a combination thereof.

14. The polymeric composition of claim 10 , wherein the radioactive isotope is 123 I.

15. The polymeric composition of claim 10 , wherein the radioactive isotope is 124 I.

16. The polymeric composition of claim 10 , wherein the radioactive isotope is 125 I.

17. The polymeric composition of claim 10 , wherein the radioactive isotope is 131 I.

18. The polymeric composition of claim 11 , further including folic acid or a functionalized form thereof.

19. A method of embolization, the method including delivering the polymeric composition of claim 1 to a lumen in need thereof.

20. A method of embolization, the method including delivering the polymeric composition of claim 10 to a lumen in need thereof.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Wu Xinping
• Fitz Matthew J
• Wu Yue

Classifications

• A61L24/001

  Use of materials characterised by their function or physical properties · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L24/0015 Primary

  Medicaments; Biocides · CPC title

• A61L2300/44

  Radioisotopes, radionuclides · CPC title

• A61L24/0005 Primary

  Ingredients of undetermined constitution or reaction products thereof · CPC title