Drug delivery device

Patent metadata

Field	Value
Publication number	US-12370304-B2
Application number	US-202217735616-A
Country	US
Kind code	B2
Filing date	May 3, 2022
Priority date	Nov 21, 2012
Publication date	Jul 29, 2025
Grant date	Jul 29, 2025

Abstract

A drug delivery device includes a blunt cannula and a reservoir. The blunt cannula has a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula. The wall has at least a first tapered region at the first end to define an opening in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula. The reservoir is connected to the second end of the blunt cannula.

First claim

We claim:

1. A wearable on-body drug delivery device comprising:
a housing having an opening;
an adhesive for attaching the wearable on-body drug delivery device to skin of a patient;
a reservoir disposed in the housing;
a volume of a drug disposed in the reservoir, the drug comprising a granulocyte colony-stimulating factor (G-CSF);
a cannula having a cylindrical wall that defines an axial passage between a first end and a second end of the cannula, the first end of the cannula disposed within the housing in an initial state and subsequently disposed through the opening in the housing for insertion into the patient in a delivery state;
a hub coupled with the second end of the cannula;
an introducer needle disposed at least partially in the cannula and configured to move relative to the cannula;
a second needle configured to facilitate fluid communication between the reservoir and the cannula in the delivery state; and
wherein the cannula defines at least one bend forming an obtuse angle.

2. The drug delivery device of claim 1 , wherein the introducer needle extends beyond the first end of the cannula when introducing the cannula into the skin of the patient.

3. The drug delivery device according to claim 1 , wherein the cannula has at least one side port formed in the wall of the cannula at the first end.

4. The drug delivery device according to claim 3 , wherein the at least one side port comprises a pair of side ports.

5. The drug delivery device according to claim 4 , wherein the pair of side ports are aligned with each other across the axial passage.

6. The drug delivery device according to claim 3 , wherein the at least one side port comprises a circular opening formed in the wall to permit flow transverse to the axial passage.

7. The drug delivery device according to claim 3 , wherein the at least one side port comprises an elongated slit formed in the wall to permit flow transverse to the axial passage.

8. The drug delivery device according to claim 3 , wherein the at least one side port comprises an elongated slot formed in the wall to permit flow transverse to the axial passage.

9. The drug delivery device according to claim 3 , wherein the first end of the cannula includes a first tapered region, and wherein the at least one side port is formed in the first end of the cannula distal from the first tapered region.

10. The drug delivery device according to claim 1 , wherein the first end of the cannula includes a first tapered region that comprises at least one bevel.

11. The drug delivery device according to claim 10 , wherein the first tapered region comprises only one bevel.

12. The drug delivery device according to claim 10 , wherein the first tapered region comprises two bevels intersecting each other.

13. The drug delivery device according to claim 10 , wherein the first tapered region comprises two negative or inverted bevels intersecting each other.

14. The drug delivery device according to claim 10 , wherein the first end of the cannula includes a pattern of openings disposed about an opening in the first tapered region.

15. The drug delivery device according to claim 14 , wherein the pattern of openings comprises a pattern of recesses into the wall.

16. The drug delivery device according to claim 1 , wherein the cannula has at least one external recessed region recessed toward the axial passage relative to adjoining surface regions.

17. The drug delivery device according to claim 16 , wherein the at least one external recessed region is defined by a pattern of ribs.

18. The drug delivery device according to claim 16 , wherein the at least one external recessed region is defined by a pattern of grooves.

19. The drug delivery device according to claim 1 , further comprising a barrel and a plunger disposed within the barrel to define the reservoir.

20. The drug delivery device according to claim 19 , further comprising a drive for moving the plunger through the barrel.

21. The wearable on-body drug delivery device of claim 1 , the hub at least partially surrounding an axis parallel to the axial passage of the cannula.

22. A method comprising:
attaching a wearable on-body drug delivery device to a patient's skin with an adhesive;
the wearable on-body drug delivery device automatically inserting a cannula into the patient's skin using an introducer needle, the cannula having a cylindrical wall that defines an axial passage between a first end and a second end of the cannula, wherein the cannula defines at least one bend forming an obtuse angle, wherein a hub is coupled with the second end of the cannula, wherein a reservoir is included in the wearable on-body drug delivery device at least when the wearable on-body drug delivery device inserts the cannula into the patient's skin, and wherein the wearable on-body drug delivery device comprises a second needle configured to facilitate fluid communication between the reservoir and the cannula; and
delivering a volume of a drug disposed in the reservoir into the patient, the drug comprising a granulocyte colony-stimulating factor (G-CSF).

23. The method of claim 22 , wherein delivering the drug comprises moving a plunger through a barrel that comprises the reservoir, the plunger forcing the drug through the cannula.

24. The method of claim 22 , the hub at least partially surrounding an axis parallel to the axial passage of the cannula.

Assignees

• Amgen Inc

Inventors

• Ring Lawrence S
• Mehta Dhairya
• Toy Stephanie
• Tamtoro Ferry
• Cairns Alexander Stuart
• Gibson Scott R

Classifications

• A61M5/14216

  Reciprocating piston type · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61M2005/3022

  Worn on the body, e.g. as patches (pressure infusion of the skin patch type A61M5/14248) · CPC title

• A61M5/3134

  characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula · CPC title

• A61M5/14

  Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor · CPC title