Drug delivery device

Patent metadata

Field	Value
Publication number	US-2016166762-A1
Application number	US-201615047835-A
Country	US
Kind code	A1
Filing date	Feb 19, 2016
Priority date	Nov 21, 2012
Publication date	Jun 16, 2016
Grant date	—

Abstract

A drug delivery device includes a blunt cannula and a reservoir. The blunt cannula has a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula. The wall has at least a first tapered region at the first end to define an opening in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula. The reservoir is connected to the second end of the blunt cannula

First claim

We claim:

1 . A wearable on-body drug delivery device comprising:
a housing; an adhesive layer attached to a surface of the housing for attaching the drug delivery device to a patient's skin; a reservoir disposed in the housing; a volume of a drug product disposed in the reservoir, the drug product comprising a granulocyte colony-stimulating factor (G-CSF); a cannula having a cylindrical wall that defines an axial passage between a first end and a second end of the cannula, the cannula configured to be operably connected in fluid communication with the reservoir to deliver the drug product to a patient during use of the drug delivery device; and an introducer needle disposed in the cannula adapted for introducing the cannula into the patient's skin and subsequently withdrawing from the cannula prior to delivery of the drug product to the patient.

2 . The drug delivery device of claim 1 , wherein the introducer needle extends beyond the first end of the cannula when introducing the cannula into the patient's skin.

3 . The drug delivery device according to claim 1 , wherein the cannula has at least one side port formed in the wall of the cannula at the first end.

4 . The drug delivery device according to claim 2 , wherein the at least side port comprises a pair of side ports.

5 . The drug delivery device according to claim 4 , wherein the pair of side ports are aligned with each other across the axial passage.

6 . The drug delivery device according to claim 3 , wherein the at least one side port comprises a circular opening formed in the wall to permit flow transverse to the axial passage.

7 . The drug delivery device according to claim 3 , wherein the at least one side port comprises an elongated slit formed in the wall to permit flow transverse to the axial passage.

8 . The drug delivery device according to claim 3 , wherein the at least one side port comprises an elongated slot formed in the wall to permit flow transverse to the axial passage.

9 . The drug delivery device according to claim 3 , wherein the at least one side port is formed in the first end of the cannula distal from the first tapered region.

10 . The drug delivery device according to claim 1 , wherein the first end of the cannula includes a first tapered region that comprises at least one bevel.

11 . The drug delivery device according to claim 10 , wherein the first tapered region comprises only one bevel.

12 . The drug delivery device according to claim 10 , wherein the first tapered region comprises two bevels intersecting each other.

13 . The drug delivery device according to claim 10 , wherein the first tapered region comprises two negative or inverted bevels intersecting each other.

14 . The drug delivery device according to claim 10 , wherein the first end of the cannula includes a pattern of openings disposed about an opening in the first tapered region.

15 . The drug delivery device according to claim 14 , wherein the pattern of openings comprises a pattern of recesses into the wall.

16 . The drug delivery device according to claim 1 , wherein the cannula has at least one external recessed region recessed toward the axial passage relative to adjoining surface regions.

17 . The drug delivery device according to claim 16 , wherein the at least one external recessed region is defined by a pattern of ribs.

18 . The drug delivery device according to claim 16 , wherein the at least one external recessed surface region is defined by a pattern of grooves.

19 . The drug delivery device according to claim 1 , further comprising a barrel and a plunger disposed within the barrel to define the reservoir.

20 . The drug delivery device according to claim 19 , further comprising a drive for moving the plunger through eth barrel.

21 . A wearable on-body drug delivery device comprising:
a housing; an adhesive layer attached to a surface of the housing for attaching the drug delivery device to a patient's skin; a reservoir disposed in the housing, the reservoir including a barrel; a plunger movably disposed in the barrel; a volume of a drug product disposed in the reservoir, the drug product comprising a granulocyte colony-stimulating factor (G-CSF); a cannula having a cylindrical wall that defines an axial passage between a first end and a second end of the cannula, the second end of the cannula configured to be operably connected in fluid communication with the reservoir; and a mechanical drive operably coupled to the plunger for moving the plunger through the barrel to deliver the drug product from the reservoir, through the cannula, and to a patient during use of the drug delivery device.

22 . The drug delivery device of claim 21 , further comprising an introducer needle disposed in the cannula adapted for introducing the cannula into the patient's skin and subsequently withdrawing from the cannula prior to delivery of the drug product to the patient.

23 . The drug delivery device of claim 22 , wherein the introducer needle extends beyond the first end of the cannula when introducing the cannula into the patient's skin.

24 . The drug delivery device according to claim 21 , wherein the cannula has at least one side port formed in the wall of the cannula at the first end.

25 . The drug delivery device according to claim 24 , wherein the at least side port comprises a pair of side ports.

26 . The drug delivery device according to claim 25 , wherein the pair of side ports are aligned with each other across the axial passage.

27 . The drug delivery device according to claim 24 , wherein the at least one side port comprises a circular opening formed in the wall to permit flow transverse to the axial passage.

28 . The drug delivery device according to claim 24 , wherein the at least one side port comprises an elongated slit formed in the wall to permit flow transverse to the axial passage.

29 . The drug delivery device according to claim 24 , wherein the at least one side port comprises an elongated slot formed in the wall to permit flow transverse to the axial passage.

30 . The drug delivery device according to claim 24 , wherein the at least one side port is formed in the first end of the cannula distal from the first tapered region.

31 . The drug delivery device according to claim 21 , wherein the first end of the cannula includes a first tapered region that comprises at least one bevel.

32 . The drug delivery device according to claim 31 , wherein the first tapered region comprises only one bevel.

33 . The drug delivery device according to claim 31 , wherein the first tapered region comprises two bevels intersecting each other.

34 . The drug delivery device according to claim 31 , wherein the first tapered region comprises two negative or inverted bevels intersecting each other.

35 . The drug delivery device according to claim 31 , wherein the first end of the cannula includes a pattern of openings disposed about an opening in the first tapered region.

36 . The drug delivery device according to claim 35 , wherein the pattern of openings comprises a pattern of recesses into the wall.

37 . The drug delivery device according to claim 21 , w

Assignees

• Amgen Inc

Inventors

• Ring Lawrence S
• Mehta Dhairya
• Toy Stephanie
• Tamtoro Ferry
• Cairns Alexander Stuart
• Gibson Scott R

Classifications

• A61M5/3134

  characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula · CPC title

• A61M25/0015

  Making lateral openings in a catheter tube, e.g. holes, slits, ports, piercings of guidewire ports; Methods for processing the holes, e.g. smoothing the edges · CPC title

• A61M5/3286

  Needle tip design, e.g. for improved penetration · CPC title

• C07K14/535

  Granulocyte CSF; Granulocyte-macrophage CSF · CPC title

• A61K38/28

  Insulins · CPC title