Drug delivery device

Patent metadata

Field	Value
Publication number	US-2015290390-A1
Application number	US-201314443847-A
Country	US
Kind code	A1
Filing date	Nov 20, 2013
Priority date	Nov 21, 2012
Publication date	Oct 15, 2015
Grant date	—

Abstract

A drug delivery device includes a blunt cannula and a reservoir. The blunt cannula has a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula. The wall has at least a first tapered region at the first end to define an opening in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula. The reservoir is connected to the second end of the blunt cannula.

First claim

1 . A drug delivery device comprising:
a blunt cannula having a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula, the wall having at least a first tapered region at the first end to define an opening in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula; and a reservoir connected to the second end of the blunt cannula.

2 . The drug delivery device according to claim 1 , wherein the blunt cannula has at least one side port formed in the wall of the blunt cannula at the first end.

3 . The drug delivery device according to claim 2 , wherein the at least side port comprises a pair of side ports.

4 . The drug delivery device according to claim 3 , wherein the pair of side ports are aligned with each other across the axial passage.

5 . The drug delivery device according to claim 2 , wherein the at least one side port comprises a circular opening formed in the wall to permit flow transverse to the axial passage.

6 . The drug delivery device according to claim 2 , wherein the at least one side port comprises an elongated slit formed in the wall to permit flow transverse to the axial passage.

7 . The drug delivery device according to claim 2 , wherein the at least one side port comprises an elongated slot formed in the wall to permit flow transverse to the axial passage.

8 . The drug delivery device according to claim 2 , wherein the at least one side port is formed in the first end of the blunt cannula distal from the first tapered region.

9 . The drug delivery device according to claim 1 , wherein the first tapered region comprises at least one bevel.

10 . The drug delivery device according to claim 9 , wherein the first tapered region comprises only one bevel.

11 . The drug delivery device according to claim 9 , wherein the first tapered region comprises two bevels intersecting each other.

12 . The drug delivery device according to claim 9 , wherein the first tapered region comprises two negative or inverted bevels intersecting each other.

13 . The drug delivery device according to claim 1 , wherein the first end includes a pattern of openings disposed about the opening in the first tapered region.

14 . The drug delivery device according to claim 13 , wherein the pattern of openings comprises a pattern of recesses into the wall.

15 . The drug delivery device according to claim 1 , wherein the blunt cannula has at least one external recessed region recessed toward the axial passage relative to adjoining surface regions.

16 . The drug delivery device according to claim 15 , wherein the at least one external recessed region is defined by a pattern of ribs.

17 . The drug delivery device according to claim 15 , wherein the at least one external recessed surface region is defined by a pattern of grooves.

18 . The drug delivery device according to claim 1 , further comprising a vibration generator coupled to the blunt cannula, the generator being actuated to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula.

19 . The drug delivery device according to claim 1 , further comprising an auto-injector, microinfuser, or infusion pump having a barrel and a plunger disposed within the barrel to define the reservoir.

20 . The drug delivery device according to claim 1 , further comprising a housing, the housing having an opening through which the cannula is disposed in an operative state, the opening having a diameter that is less than twice the diameter of the cannula.

21 . A drug delivery device comprising:
a blunt cannula having a cylindrical wall that defines an axial passage between a closed first end and a second end of the blunt cannula, the wall having a first tapered region at the first end with at least one side opening in fluid communication with the axial passage adapted to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula; and a reservoir connected to the second end of the blunt cannula.

22 . The drug delivery device according to claim 21 , further comprising a housing, the housing having an opening through which the cannula is disposed in an operative state, the opening having a diameter that is less than twice the diameter of the cannula.

23 . A drug delivery device comprising:
a blunt cannula having a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula, the wall having in a first tapered region at the first end to define an opening in fluid communication with the axial passage; a vibration generator coupled to the blunt cannula, the generator being actuated to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula; and a reservoir connected to the second end of the blunt cannula.

24 . The drug delivery device according to claim 23 , wherein the vibration generator comprises a motor with a shaft and an eccentric weight attached to the shaft.

25 . The drug delivery device according to claim 23 , wherein the vibration generator comprises a piezoelectric vibrator.

26 . The drug delivery device according to claim 23 , further comprising a housing, the housing having an opening through which the cannula is disposed in an operative state, the opening having a diameter that is less than twice the diameter of the cannula.

27 . A drug delivery device comprising:
a rigid needle having a cylindrical wall that defines an axial passage between a first end and a second end of the rigid needle, the wall having an opening at the first end in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the rigid needle; and a reservoir connected to the second end of the rigid needle, wherein the adaptation at the first end includes at least one of a pattern of openings disposed about the opening in the first tapered region, and at least one external recessed region recessed toward the axial passage relative to adjoining surface regions.

28 . The drug delivery device according to claim 27 , wherein the pattern of openings comprises a pattern of recesses into the wall.

29 . The drug delivery device according to claim 27 , wherein the at least one external recessed region is defined by a pattern of ribs.

30 . The drug delivery device according to claim 27 , wherein the at least one external recessed surface region is defined by a pattern of grooves.

31 . The drug delivery device according to claim 27 , further comprising a vibration generator coupled to the rigid needle, the generator being actuated to resist interruption of fluid flow through the axial passage and out of the first end of the rigid needle.

32 . The drug delivery device according to claim 27 , further comprising an auto-injector, microinfuser, or infusion pump having a barrel and a plunger disposed within the barrel to define the reservoir.

33 . The drug delivery device according to claim 27 , further comprising a housing, the housing having an opening through which the rigi

Assignees

• Amgen Inc

Inventors

• Ring Lawrence
• Mehta Dhairya
• Toy Stephanie
• Tamtoro Ferry
• Cairns Alexander Stuart
• Gibson Scott R

Classifications

• A61M5/3291 Primary

  Shafts with additional lateral openings · CPC title

• A61M5/20

  Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 {, A61M5/46} take precedence; {hypodermic projectiles F42B12/54}) · CPC title

• A61M5/14248 Primary

  of the skin patch type · CPC title

• A61M2005/3022

  Worn on the body, e.g. as patches (pressure infusion of the skin patch type A61M5/14248) · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title