Holder for a capillary triggered to hold when a capillary is inserted

Patent metadata

Field	Value
Publication number	US-12368036-B2
Application number	US-202117998000-A
Country	US
Kind code	B2
Filing date	May 5, 2021
Priority date	May 5, 2020
Publication date	Jul 22, 2025
Grant date	Jul 22, 2025

Abstract

A holder for a capillary, comprising: a housing having a passage to receive a capillary; and a clamping mechanism configurable between: an engaged state in which the clamping mechanism is configured to retain a capillary receivable in the passage in use; and a disengaged state in which the clamping mechanism is configured to allow insertion/removal of a capillary in the passage in use; and a release mechanism operatively associated with the clamping mechanism and movable between a first position, in which the clamping mechanism is configured in said engaged state; and a second position, in which the clamping mechanism is configured in aid disengaged state, wherein the release mechanism is configured to bias the clamping mechanism towards the engaged state, wherein the passage in the housing comprises an end stop, configured to abut the end of a capillary inserted in the passage in use.

First claim

The invention claimed is:

1. A holder for a capillary, comprising:
a housing having a passage to receive a capillary;
a clamping mechanism configurable between:
an engaged state in which the clamping mechanism is configured to retain a capillary receivable in the passage in use; and
a disengaged state in which the clamping mechanism is configured to allow insertion/removal of a capillary in the passage in use; and

a trigger operatively associated with the clamping mechanism, configured to change the clamping mechanism from said disengaged state to said engaged state by inserting a capillary into the passage.

2. A holder according to claim 1 , wherein the trigger is configured to change the clamping mechanism from said disengaged state to said engaged state by engaging the capillary with the trigger.

3. A holder according to claim 1 , further comprising a release mechanism operatively associated with the clamping mechanism, configured to change the clamping mechanism from said engaged state to said disengaged state upon a user operating the release mechanism.

4. A holder according to claim 3 , configured to eject a capillary retained in the passage as the release mechanism changes the clamping mechanism to said disengaged state.

5. A holder according to claim 3 , wherein the release mechanism is movable between a first position, in which the clamping mechanism is configured in said engaged state; and a second position, in which the clamping mechanism is configured in said disengaged state.

6. A holder according to claim 5 , wherein the release mechanism is biased towards the first position.

7. A holder according to claim 5 , wherein the release mechanism comprises a carriage translatably received in the housing, the trigger comprises a plunger arranged in the carriage and configured to protrude from the carriage and be received in the passage when the carriage is in the second position, and be retained in the carriage when the carriage is in the first position.

8. A holder according to claim 7 , wherein the plunger is biased to protrude from the carriage.

9. A holder according to claim 3 , wherein the clamping mechanism comprises:
a clamping arm, pivotably mounted at a first end to the housing and pivotably mounted at a second end to the release mechanism; and
a clamping element mounted to the clamping arm between the first and second ends.

10. A holder according to claim 9 , wherein the clamping element is pivotably mounted to the clamping arm.

11. A holder according to claim 9 , wherein the clamping element comprises a capillary-engaging tooth at each of the first and second ends of the clamping element.

12. A holder according to claim 9 , wherein the clamping element comprises a leaf spring.

13. A holder according to claim 1 , wherein the passage is at least partially defined by a bore of the housing.

14. A holder according to claim 1 , further comprising a capillary, wherein the clamping mechanism is configured in said engaged state such that at least a portion of the capillary is substantially retained in the passage.

Assignees

• Micromass Ltd

Inventors

• Ngo Pham Hoang Vu
• Rangan Arvind
• Lum Veronica
• Chen Carl
• Lumley Nicola
• Douce David

Classifications

• H01J49/0409

  Sample holders or containers (containers for retaining a material to be analyzed, B01L3/50, for DNA, C12Q1/6834, for biological materials, G01N33/543) · CPC title

• H01J49/0404 Primary

  Capillaries used for transferring samples or ions (electrospray nozzles H01J49/167) · CPC title