Method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells
US-10337012-B2 · Jul 2, 2019 · US
Surfactant peptide nanostructures and uses thereof in drug delivery
US12239744B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12239744-B2 |
| Application number | US-202217722357-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 17, 2022 |
| Priority date | Dec 15, 2017 |
| Publication date | Mar 4, 2025 |
| Grant date | Mar 4, 2025 |
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- Title
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Abstract
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Disclosed herein are surfactant peptide nanostructures wherein the peptides have repeating hydrophobic amino acids in an integer equal to or less than four. The peptide nanostructures are useful for therapeutic applications, including for delivery of drugs and siRNA.
First claim
Opening claim text (preview).
What is claimed is: 1. A drug delivery composition, said drug delivery composition comprising a peptide that consists of the amino acid sequence of AAAK (SEQ ID NO:1), wherein the peptide is present at a concentration of at least 0.01% (w/v) in an aqueous solution that has a pH from about 6 to about 8, and wherein the peptide is complexed with an siRNA. 2. The drug delivery composition of claim 1 , wherein the aqueous solution is at an ionic strength of up to 0.3 M. 3. The drug delivery composition of claim 1 , wherein the aqueous solution is isotonic. 4. The drug delivery composition of claim 1 , wherein the siRNA is for delivery to a cancer cell. 5. The drug delivery composition of claim 1 , wherein each amino acid is a D-amino acid. 6. The drug delivery composition of claim 1 , wherein the peptide is amidated at the C-terminus and acetylated at the N-terminus.
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Classifications
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title
Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links · CPC title
Processes · CPC title
Solutions {(composition of solutions A61K47/00)} · CPC title
Double-stranded nucleic acids or oligonucleotides · CPC title
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Frequently asked questions
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- What does patent US12239744B2 cover?
- Disclosed herein are surfactant peptide nanostructures wherein the peptides have repeating hydrophobic amino acids in an integer equal to or less than four. The peptide nanostructures are useful for therapeutic applications, including for delivery of drugs and siRNA.
- Who is the assignee on this patent?
- 3 D Matrix Ltd
- What technology area does this patent fall under?
- Primary CPC classification A61K9/5169. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).