Transfection agent
US-9133484-B2 · Sep 15, 2015 · US
Method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells
US10337012B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10337012-B2 |
| Application number | US-201715410480-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 19, 2017 |
| Priority date | Aug 20, 2010 |
| Publication date | Jul 2, 2019 |
| Grant date | Jul 2, 2019 |
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Abstract
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The invention provides a method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells.
First claim
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The invention claimed is: 1. A method of treating a cancer containing or derived from cancer stem cells comprising a step of administering an siRNA-carrier complex comprising an siRNA against ribophorin II (RPN2) and a transport carrier to a subject in need thereof, wherein the cancer stem cells have a mutated p53 gene, and wherein the siRNA interferes with RPN2 gene expression in an in vitro assay. 2. The method of claim 1 , wherein the transport carrier comprises the peptide AAAAAAK (SEQ ID NO: 26). 3. The method of claim 1 , wherein the siRNA-carrier complex is administered locally. 4. The method of claim 1 , wherein the siRNA-carrier complex is administered systemically. 5. The method of claim 1 , wherein a double-stranded region of the siRNA is 19 bases in length. 6. The method of claim 1 , wherein a double-stranded region of the siRNA comprises position of 1,194 of the RPN2 gene sequence (SEQ ID NO: 1). 7. The method of claim 1 , wherein a double-stranded region of the siRNA corresponds to at least position 1,212 of the RPN2 gene sequence (SEQ ID NO: 1). 8. The method of claim 1 , wherein the siRNA corresponds to positions comprises 1,194-1,212 of the RPN2 gene sequence (SEQ ID NO: 1). 9. The method of claim 1 , wherein the siRNA comprises RNA comprises SEQ ID NO: 2. 10. The method of claim 1 , wherein the siRNA comprises RNA comprising SEQ ID NO: 3. 11. The method of claim 1 , further comprising administering a substance for introducing a nucleic acid. 12. The method of claim 11 , wherein the substance for introducing a nucleic acid is liposome.
Assignees
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Classifications
Hexosyltransferases (general) (2.4.1) · CPC title
Dolichyl-diphosphooligosaccharide—protein glycotransferase (2.4.99.18) · CPC title
Expression markers · CPC title
Prognosis of disease development · CPC title
Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism · CPC title
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- What does patent US10337012B2 cover?
- The invention provides a method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells.
- Who is the assignee on this patent?
- 3 D Matrix Ltd, Nat Cancer Ct
- What technology area does this patent fall under?
- Primary CPC classification C12N15/1137. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jul 02 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).