Method for stabilizing retinoic acid precursors and a skin benefit composition with stabilized retinoic acid precursors

Patent metadata

Field	Value
Publication number	US-12233144-B2
Application number	US-202318383061-A
Country	US
Kind code	B2
Filing date	Oct 24, 2023
Priority date	May 12, 2016
Publication date	Feb 25, 2025
Grant date	Feb 25, 2025

Abstract

A method for stabilizing retinoic acid precursors and a skin benefit composition with stabilized retinoic acid precursors are described. The composition has a retinoic acid precursor and a resorcinol to impede oxidation of the precursor in situ in the composition.

First claim

The invention claimed is:

1. A composition comprising:
(a) a retinoic acid precursor selected from retinyl propionate, hydroxyanasatil retinoate, and mixtures thereof; and
(b) a skin benefit agent selected from 4-ethyl resorcinol, 4-butyl resorcinol, 4-hexyl resorcinol, 4-isopropyl resorcinol and mixtures thereof; and
(c) at least one humectant,
wherein the retinoic acid precursor and the skin benefit agent are present at a weight ratio of from about 1:2 to about 2:1; and
wherein the pH is from 4 to 8.

2. The composition according to claim 1 , wherein the retinoic acid precursor is present from 0.001 to 10% by weight of the composition, and the skin benefit agent is present from 0.001 to 10% of the composition.

3. The composition of claim 1 , wherein the humectant is selected from polyhydric alcohols, propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, isoprene glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol, and mixtures thereof.

4. The composition of claim 3 , wherein the polyhydric alcohol is glycerol.

5. The composition according to claim 1 further comprising a retinoid booster selected from climbazole, bibonazole, farnesol, glycyrrhetinic acid, ursolic acid, geranyl geraniol, oleyl betaine, hexanoyl sphingosine, and combinations thereof.

6. The composition according to claim 1 further comprises at least one component selected from creatine, 1,2-octanediol, sunscreen, conjugated linoleic acid, hydroxyl acid, 12-hydroxystearic acid, phenoxyethanol, glyceryl stearate, glycol stearate, stearamide AMP, PEG-100 stearate, cetyl alcohol, and combinations thereof.

7. The composition according to claim 1 further comprising at least one vitamin selected from Vitamin B2, Vitamin B3, Vitamin B6, Vitamin C, Vitamin E, Folic Acid, Biotin, and combinations thereof.

8. The composition according to claim 1 , wherein the composition is not an emulsion.

9. The composition according to claim 1 , wherein the composition is an oil-in-water emulsion.

10. The composition according to claim 1 , wherein the composition is an water-in-oil emulsion.

11. The composition according to claim 1 , wherein the skin benefit agent impedes oxidation of the retinoic acid precursor in the composition.

12. A method for impeding oxidation comprising a step of topically applying to skin the composition of claim 1 .

Assignees

• Conopco Inc

Inventors

• Lou Anjing
• Moaddel Teanoosh
• Patel Anil Babubhai

Classifications

• A61G19/00

  Hoisting or lowering devices for coffins · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title

• A61K8/361

  Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof · CPC title

• A61K8/062

  Oil-in-water emulsions · CPC title

• A61K2800/52

  Stabilizers · CPC title