Compounds and methods for treatment of viral infections

Patent metadata

Field	Value
Publication number	US-12180217-B2
Application number	US-202418601528-A
Country	US
Kind code	B2
Filing date	Mar 11, 2024
Priority date	Mar 2, 2022
Publication date	Dec 31, 2024
Grant date	Dec 31, 2024

Abstract

Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

First claim

The invention claimed is:

1. A compound of Formula:

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound is

3. A compound of Formula:

or a pharmaceutically acceptable salt thereof.

4. The compound of claim 3 , wherein the compound is

5. A compound of Formula:

or a pharmaceutically acceptable salt thereof.

6. The compound of claim 5 , wherein the compound is

7. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

8. A pharmaceutical composition comprising the compound of claim 2 , and one or more pharmaceutically acceptable excipients.

9. A pharmaceutical composition comprising the compound of claim 3 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

10. A pharmaceutical composition comprising the compound of claim 4 , and one or more pharmaceutically acceptable excipients.

11. A pharmaceutical composition comprising the compound of claim 5 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

12. A pharmaceutical composition comprising the compound of claim 6 , and one or more pharmaceutically acceptable excipients.

Assignees

• Gilead Sciences Inc

Inventors

• Bartlett Mark J
• Byun Daniel H
• Deng Yifan
• Cosman Ellis Jennifer L
• Kalla Rao V
• Mackman Richard L
• Siegel Dustin S
• Zeng Xianhuang

Classifications

• C07F9/6561

  containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings · CPC title

• C07D519/00

  Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K9/0053

  Mouth and digestive tract, i.e. intraoral and peroral administration · CPC title

• A61P31/14 Primary

  for RNA viruses · CPC title