Substituted nucleotide analogs

Patent metadata

Field	Value
Publication number	US-8980865-B2
Application number	US-201213722472-A
Country	US
Kind code	B2
Filing date	Dec 20, 2012
Priority date	Dec 22, 2011
Publication date	Mar 17, 2015
Grant date	Mar 17, 2015

Abstract

Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoroamidate prodrugs and thiophosphates (including α-thiomonophosphates, α-thiodiphosphates, and α-thiotriphosphates), methods of synthesizing phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates and methods of treating viral infections, such as HCV, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates.

First claim

What is claimed is:

1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof:

wherein:
B 1 is an optionally substituted heterocyclic base or an optionally substituted heterocyclic base with a protected amino group;
R 1 is selected from the group consisting of O − , OH, an optionally substituted N-linked amino acid and an optionally substi…

Assignees

• Alios Biopharma Inc

Inventors

• Wang Guangyi
• Beigelman Leonid

Classifications

• A61P31/14

  Human Necessities · mapped topic

• A61P31/12

  Human Necessities · mapped topic

• A61K31/7072 Primary

  Human Necessities · mapped topic

• A61K45/06

  Human Necessities · mapped topic

• A61K31/497

  Human Necessities · mapped topic