Substituted nucleosides, nucleotides and analogs thereof

Patent metadata

Field	Value
Publication number	US-9243022-B2
Application number	US-201314135484-A
Country	US
Kind code	B2
Filing date	Dec 19, 2013
Priority date	Dec 21, 2012
Publication date	Jan 26, 2016
Grant date	Jan 26, 2016

Abstract

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.

First claim

What is claimed is:

1. A compound of the structure

or a pharmaceutically acceptable salt thereof.

2. A compound of the structure

or a pharmaceutically acceptable salt thereof.

3. A compound of the structure

or a pharmaceutically acceptable salt thereof.

4. A compound of the structure

or a pharmaceutically acceptable salt thereof.

5. A compound of the structure

or a pharmaceutically acceptable salt thereof.

6. A compound of the structure

or a pharmaceutically acceptable salt thereof.

7. A compound of the structure

or a pharmaceutically acceptable salt thereof.

8. A compound of the structure

or a pharmaceutically acceptable salt thereof.

Assignees

• Alios Biopharma Inc

Inventors

• Beigelman Leonid
• Wang Guangyi
• Smith David Bernard

Classifications

• C07H19/213 Primary

  containing cyclic phosphate · CPC title

• C07H19/16

  Purine radicals · CPC title

• C07H19/06 Primary

  Pyrimidine radicals · CPC title

• C07H19/10 Primary

  with the saccharide radical esterified by phosphoric or polyphosphoric acids · CPC title

• A61P31/14

  for RNA viruses · CPC title