Automated fluid handling system

Patent metadata

Field	Value
Publication number	US-12072344-B2
Application number	US-202318131043-A
Country	US
Kind code	B2
Filing date	Apr 5, 2023
Priority date	Jun 9, 2009
Publication date	Aug 27, 2024
Grant date	Aug 27, 2024

Abstract

Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.

First claim

The invention claimed is:

1. A column valve for an automated liquid chromatography system, the column valve comprising:
i. two or more pairs of column connection ports each for connecting a chromatography column therebetween;
ii. an inlet port;
iii. an outlet port;
wherein the valve is configured for selective connection of a column connected to a pair of column connector ports by connecting the inlet port to one of the ports in the pair of column connector ports and the outlet port to the other port of the pair of column connector ports, and wherein the valve further comprises integrated pressure sensors integrated into the inlet and outlet ports of the valve, whereby the automated liquid chromatography system can measure the actual pressure over the connected column, and a liquid flow direction can be set from the top of the column to the bottom of the column, and from the bottom of the column to the top of the column.

2. The column valve of claim 1 , wherein the valve has a built-in bypass capillary that enables bypassing of connected columns.

3. The column valve of claim 1 , wherein the valve is a motorized rotary valve.

4. The column valve of claim 1 , wherein the liquid chromatography system comprises a master control unit arranged to automatically detect fluid handling units when inserted into the fluid handling unit receiving positions.

5. The column valve of claim 1 , the column valve forms part of a fluid handling unit, the fluid handling unit corresponding in size and shape to a corresponding fluid handling unit receiving position of the automated liquid chromatography system, wherein said liquid chromatography system is adapted to allow each fluid handling unit to be freely and independently positioned in any one of the fluid handling unit receiving positions of a housing unit.

6. The column valve of claim 5 , wherein an internal section of the at least one fluid handling unit comprises electronics, electrical components, or control means.

7. The column valve of claim 5 , wherein the fluid handling unit comprises an enclosure with one or more air inlet openings.

8. The column valve of claim 7 , wherein the one or more air inlet openings are on the section of the fluid handling unit that is inserted into the fluid handling unit receiving position of the housing unit.

9. The column valve of claim 5 , the column valve further comprising a dedicated CPU allowing the fluid handling unit to perform operation in response to instructions over a system bus.

Assignees

• Cytiva Sweden Ab
• Ge Healthcare Bio Science Ab

Inventors

• Blomberg Johan
• Lundkvist Mats

Classifications

• G01N2030/027

  Liquid chromatography · CPC title

• G01N30/38

  Flow patterns · CPC title

• G01N30/24

  Automatic injection systems · CPC title

• G01N2030/8804

  automated systems · CPC title

• B01D29/60

  integrally combined with devices for controlling the filtration · CPC title