Method of producing capsules and related capsules

Patent metadata

Field	Value
Publication number	US-12053754-B2
Application number	US-201917279001-A
Country	US
Kind code	B2
Filing date	Sep 24, 2019
Priority date	Sep 24, 2018
Publication date	Aug 6, 2024
Grant date	Aug 6, 2024

Abstract

There is provided a method of producing silica capsules, the method comprising: adding a silica precursor to emulsified droplets in the presence of salt and alcohol to enhance silica growth around the emulsified droplets by an ion association effect, thereby forming silica capsules. Also provided are silica capsules producible by such a method.

First claim

The invention claimed is:

1. A method of producing silica capsules, the method comprising:
adding a silica precursor to emulsified droplets in the presence of a salt at a concentration of from 10 mM to 20 mM and an alcohol at a concentration of at least about 20% v/v to produce an ion association effect to enhance silica growth around the emulsified droplets, thereby forming silica capsules.

2. The method of claim 1 , wherein the adding step is carried out in an acidic pH environment.

3. The method of claim 2 , wherein the acidic pH is from pH 2 to pH 5.

4. The method of claim 1 , wherein the salt comprises a metal salt selected from the group consisting of a sodium salt, a potassium salt, a calcium salt, an aluminum salt, and combinations thereof.

5. The method of claim 4 , wherein the salt comprises a metal salt selected from the group consisting of sodium chloride, potassium chloride, calcium chloride, aluminum chloride, and combinations thereof.

6. The method of claim 1 , wherein the alcohol is selected from the group consisting of: methanol, ethanol, propanol, isopropanol and combinations thereof.

7. The method of claim 1 , wherein the silica precursor comprises an alkoxy silane.

8. The method of claim 1 , wherein the method is carried out at a temperature of no more than about 60° C.

9. The method of claim 1 , wherein the emulsified droplets are substantially non-polar.

10. The method of claim 1 , further comprising dispersing a substantially non-polar substance in a polar solvent to obtain the emulsified droplets.

11. The method of claim 1 , further comprising evaporating the emulsified droplets encapsulated by the silica capsules to obtain hollow silica capsules.

12. The method of claim 1 , wherein the method is carried out using water as the primary medium.

13. The method of claim 12 , further comprising concentrating the silica capsules to an amount of at least about 30 wt % in water.

14. A silica capsule produced by the method of claim 1 , wherein the silica capsule is no more than about 100 microns in size and is substantially resistant to breaking under scanning electron microscopy (SEM) vacuum conditions.

15. The silica capsule of claim 14 , further comprising a substantially non-polar substance encapsulated by the silica capsule.

16. The silica capsule of claim 15 , wherein the substantially non-polar substance is selected from the group consisting of: aroma, flavour, fragrance, perfume, drug, therapeutic, phase change material, cosmetic, skin care substance, silicone oil, pentane, dodecane and combinations thereof.

17. The silica capsule of claim 14 , wherein the silica capsule is substantially hollow.

18. The silica capsule of claim 14 , wherein the silica capsule has one or more of the following properties: (i) capable of being loaded with cargo of at least about 80% by weight of the loaded silica capsule without substantial breakage; (ii) capable of being concentrated in water to a concentration of at least about 30 wt % without substantial breakage, (iii) capable of being subjected to scanning electron microscopy (SEM) vacuum conditions without substantial breakage, and (iv) is stable under ambient conditions for no less than about 6 months without substantial breakage.

Assignees

• Agency Science Tech & Res

Inventors

• Thoniyot Praveen
• Van Herk Alexander M

Classifications

• C01B33/14

  Colloidal silica, e.g. dispersions, gels, sols · CPC title

• C11D7/261

  Alcohols; Phenols · CPC title

• C11D7/10

  Salts · CPC title

• C11D7/20

  Water-insoluble oxides · CPC title

• C11D3/2006

  Monohydric alcohols · CPC title