Method and system for refining long chain dicarboxylic acid

Patent metadata

Field	Value
Publication number	US-12017182-B2
Application number	US-202117507959-A
Country	US
Kind code	B2
Filing date	Oct 22, 2021
Priority date	Dec 24, 2019
Publication date	Jun 25, 2024
Grant date	Jun 25, 2024

Abstract

The present disclosure provides a system for refining long chain dicarboxylic acid, comprising: a first membrane filtration unit, for a first membrane filtration of a long chain dicarboxylic acid fermentation broth or a treated liquid therefrom; a first decolorization unit, for carrying out a first decolorization treatment to the filtrate obtained after the membrane filtration; a first acidification/crystallization unit, for carrying out a first acidification/crystallization of a filtrate obtained after the membrane filtration to give a solid-liquid mixture; a first separation unit, for a solid-liquid separation of the solid-liquid mixture; a drying unit, for drying the solid separated by the separation unit to give a first solid. By using the refining system according to the present disclosure, the purity of the obtained product is high, and the disadvantages such as poor quality of the product obtained by crystallization from a solvent and environment pollution caused by a solvent can be overcome.

First claim

The invention claimed is:

1. A system for refining long chain dicarboxylic acid, comprising:
a first membrane filtration unit, for a first membrane filtration of a long chain dicarboxylic acid fermentation broth or a treated liquid therefrom;
a first decolorization unit, for carrying out a first decolorization treatment to the filtrate obtained after the membrane filtration;
a first acidification/crystallization unit, for carrying out an acidification/crystallization of a filtrate obtained after the membrane filtration to give a solid-liquid mixture;
a first separation unit, for a solid-liquid separation of the solid-liquid mixture;
a drying unit, for drying the solid separated by the separation unit to give a first solid;
wherein a microfiltration membrane filtration device comprising a microfiltration membrane, an ultrafiltration membrane filtration device comprising an ultrafiltration membrane, and a cooling device are disposed in the first membrane filtration unit; after the microfiltration membrane filtration, the resulted filtrate from the fermentation broth or the treated liquid therefrom is cooled to 20 to 45° C. in the cooling device, and subjected to the ultrafiltration membrane filtration.

2. The refining system according to claim 1 , wherein a temperature for the microfiltration membrane filtration is 30 to 100° C.; and/or
a pore size of the microfiltration membrane is 0.01 to 1 μm; and/or
the pressure difference on both sides of the membrane during microfiltration filtration is controlled to be 0.05 to 0.5 MPa; and/or
a temperature for the ultrafiltration membrane filtration is 20 to 100° C.; and/or
a cut-off molecular weight of the ultrafiltration membrane is 1000 to 200000 Da.

3. The refining system according to claim 1 , wherein a temperature for the first decolorization treatment is 50 to 100° C.; and/or
the acidification/crystallization comprises adjusting the filtrate to pH 2 to 4.5 for crystallization to occur.

4. The refining system according to claim 1 , further comprising a vacuum distillation unit, for carrying out separation by distillation on the first solid to obtain a second solid.

5. The refining system according to claim 4 , wherein a pressure of the vacuum distillation is ≤100 Pa; and/or the vacuum distillation unit comprises a molecular distillation device for carrying out a molecular distillation or a rectifying column for carrying out a high vacuum distillation.

6. The refining system according to claim 5 , wherein the number of plates of the rectifying column is 8 to 24, and/or,
the rectifying column has an overhead pressure of 1 to 100 Pa, and/or,
the rectifying column has an overhead temperature of 160 to 250° C., and/or,
the rectifying column has a bottom temperature of 180 to 270° C., and/or,
the rectifying column has a reflux ratio of (1 to 10):1.

7. The refining system according to claim 5 , wherein a pressure in a main evaporator for the molecular distillation is 0.1 to 30 Pa, and/or
the temperature of the evaporation surface of the main evaporator is 130 to 250° C., and/or
the temperature of the condensation surface of the main evaporator is 130 to 160° C.

8. The refining system according to claim 4 , comprising a second decolorization unit, which is disposed between the drying unit and the vacuum distillation unit, for carrying out a decolorization treatment to the first solid; or
the second decolorization unit is disposed after the vacuum distillation unit, for carrying out a decolorization treatment to the product obtained after the vacuum distillation.

9. The refining system according to claim 8 , wherein the decolorization treatment comprises a melt decolorization; said melt decolorization comprises heating the solid to be decolorized to melt, and passing the same in melt form over a decolorant.

10. The refining system according to claim 9 , wherein the temperature for the melt decolorization is 130 to 180° C.; and/or the decolorant is an activated carbon, in the melt decolorization, the amount of the activated carbon is 3 to 50 wt % of the mass of the solid to be decolorized.

11. The refining system according to claim 8 , wherein a second acidification/crystallization unit and a second separation unit are disposed between the second decolorization unit and the vacuum distillation unit.

12. The refining system according to claim 1 , wherein the pH of the fermentation broth or the treated liquid therefrom is 6 to 12; and/or
before the first membrane filtration, the fermentation broth or the treated liquid therefrom is heated to 60 to 100° C., and/or
before the first filtration unit, a feedstock storage tank and a heating device are disposed, for heating the fermentation broth or the treated liquid therefrom to 60 to 100° C.

13. The refining system according to claim 1 , wherein a second membrane filtration unit, a second decolorization unit, a second acidification/crystallization unit, a second separation unit which are sequentially connected, are disposed between the first separation unit and said drying unit; in the second membrane filtration unit, a dissolution tank and a filtration membrane are disposed, said filtration membrane is an ultrafiltration membrane or a microfiltration membrane.

14. The refining system according to claim 13 , wherein a third membrane filtration unit is disposed between the second membrane filtration unit and the second decolorization unit; and/or
a third membrane filtration unit is disposed between said second decolorization unit and said acidification/crystallization unit.

15. The refining system according to claim 14 , wherein a filtration membrane is disposed in the third membrane filtration unit, said membrane filtration unit is an ultrafiltration membrane.

16. The refining system according to claim 1 , wherein a decolorization tank, a plate-and-frame filter and a heating device are disposed in the first decolorization unit.

17. The refining system according to claim 12 , wherein the pH of the fermentation broth or the treated liquid therefrom is 8 to 11.

18. A system for refining long chain dicarboxylic acid, comprising:
a first membrane filtration unit, for a first membrane filtration of a long chain dicarboxylic acid fermentation broth or a treated liquid therefrom;
a first decolorization unit, for carrying out a first decolorization treatment to the filtrate obtained after the membrane filtration;
a first acidification/crystallization unit, for carrying out an acidification/crystallization of a filtrate obtained after the membrane filtration to give a solid-liquid mixture;
a first separation unit, for a solid-liquid separation of the solid-liquid mixture;
a drying unit, for drying the solid separated by the separation unit to give a first solid;
a vacuum distillation unit, for carrying out separation by distillation on the first solid to obtain a second solid;
wherein a pressure of the vacuum distillation is ≤100 Pa; and the vacuum distillation unit comprises a rectifying column for carrying out a high vacuum distillation, and
wherein the number of plates of the rectifying column is 8 to 24, and/or,
the rectifying column has an overhead pressure of 1 to 100 Pa, and/or,
the rectifying column has an overhead temperature of 160 to 250° C., and/or,
the rectifying column has a bottom temperature of 180 to 270° C., and/or,
the rectifying column has a reflux ratio of (1 to 10):1.

19. The refining system according to claim 18 , wherein the first membrane filtration unit comprises a microfiltration membrane and/or

Assignees

• Cathay Biotech Inc
• Cibt America Inc
• Cathay Jinxiang Biomaterial Co Ltd

Inventors

• Yang Chen
• Qin Bingbing
• Yang Yufeng
• Wang Kai
• Liu Xiucai

Classifications

• B01D2325/0283

  Pore size · CPC title

• B01D61/149

  Multistep processes comprising different kinds of membrane processes selected from ultrafiltration or microfiltration · CPC title

• B01D2311/106

  Cooling · CPC title

• B01D2311/103

  Heating · CPC title

• B01D29/00

  Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor · CPC title