Method and system for obtaining a carboxylic acid which is produced in a fermentation process

Patent metadata

Field	Value
Publication number	US-2018290961-A1
Application number	US-201615754371-A
Country	US
Kind code	A1
Filing date	Aug 26, 2016
Priority date	Sep 2, 2015
Publication date	Oct 11, 2018
Grant date	—

Abstract

A plant and a process may be utilized to isolate a carboxylic acid from a fermentation broth. The process may involve separating a biomass from the fermentation broth containing a salt of the carboxylic acid to produce a low-biomass solution. The separation of the biomass may be performed in a first step by centrifugation, separation, precoat filtration, or microfiltration, and in a second step by ultrafiltration. The process may further involve concentrating the salt of the carboxylic acid in the low-biomass solution. The concentrated solution may then be acidified. Further, precipitation of the carboxylic acid may be obtained by acidification.”

First claim

1 .- 16 . (canceled)

17 . A process for isolating a carboxylic acid from a fermentation broth, the process comprising:
separating a biomass from the fermentation broth containing a salt of the carboxylic acid to produce a low-biomass solution; concentrating the salt of the carboxylic acid in the low-biomass solution to form a concentrated solution; acidifying the concentrated solution; and precipitating the carboxylic acid obtained by acidification.

18 . The process of claim 17 wherein the separation of the biomass is performed in a first step by centrifugation, separation, precoat filtration, or microfiltration, and in a second step by ultrafiltration.

19 . The process of claim 17 wherein prior to the acidification of the concentrated solution, the process comprises purifying the low-biomass solution or the concentrated solution by at least one of nanofiltration, cation exchange, anion exchange, or activated carbon purification.

20 . The process of claim 17 wherein a concentration of the concentrated solution is above a solubility concentration of the carboxylic acid.

21 . The process of claim 17 wherein the salt of the carboxylic acid is concentrated from 1%-10% by weight to 40%-50% by weight.

22 . The process of claim 17 wherein the salt of the carboxylic acid is concentrated from 3%-7% by weight to 20%-25% by weight.

23 . The process of claim 17 wherein concentrating the salt of the carboxylic acid in the low-biomass solution comprises a membrane process performed in one, two, or more stages.

24 . The process of claim 23 wherein the membrane process is at least one of nanofiltration, reverse osmosis, high-pressure reverse osmosis, or membrane distillation.

25 . The process of claim 17 wherein
a pH of the concentrated solution after the concentration is between 5.0 and 8.0; or
a pH in the concentrated solution after the acidification is between 1.8 and 3.0.

26 . The process of claim 17 wherein the precipitation of the carboxylic acid is performed by way of a crystallization comprising cooling crystallization and isolation of the crystallized carboxylic acid.

27 . The process of claim 26 wherein a mother liquor remaining after isolation of the crystallized carboxylic acid is, after a concentration of the carboxylic acid present therein has been increased, fed to the cooling crystallization.

28 . The process of claim 17 wherein concentrating the salt of the carboxylic acid is performed with at least partial recovery of energy consumed by concentrating the salt of the carboxylic acid.

29 . The process of claim 17 wherein prior to the acidification of the concentrated solution, the process comprises purifying the low-biomass solution or the concentrated solution, wherein the concentration or the purification is performed with at least partial recovery of energy consumed by the concentration or a fine purification step.

30 . The process of claim 17 comprising feeding discharge streams obtained in the concentration to an upstream portion of the process or to an esterification.

31 . The process of claim 17 wherein
the carboxylic acid has a solubility at 20° C. of 5 to 110 g/l;
the carboxylic acid is at least one of fumaric acid, succinic acid, adipic acid, itaconic acid, threonine, methionine, aspartic acid, glutamic acid, oxalic acid, asparagine, glutamine, histidine, isoleucine, leucine, phenylalanine, tryptophan, tyrosine, or valine; or
the salt of the carboxylic acid in the concentrated solution has a two-fold or five-fold greater solubility than the carboxylic acid.

32 . A plant for isolating a carboxylic acid from a fermentation broth containing salt of the carboxylic acid, the plant comprising:
a separation unit for separating biomass from the fermentation broth; a concentration unit downstream of the separation unit for concentrating the salt of the carboxylic acid in a low-biomass fermentation broth to form a concentrated solution; and an acidification unit downstream of the concentration unit for acidifying the concentrated solution.

33 . The plant of claim 32 wherein
the separation unit is configured for performing a centrifugation, a separation, a precoat filtration, a microfiltration, or an ultrafiltration;
the concentration unit is configured for performing a nanofiltration, a reverse osmosis, a high-pressure reverse osmosis, or a membrane distillation;
the acidification unit is a settling vessel having a conical bottom and a discharge device disposed in a tip of a cone of the settling vessel; or
the plant comprises a purification unit disposed between the separation unit and the concentration unit for purifying the salt of the carboxylic acid in the low-biomass fermentation broth, wherein the purification unit is configured for performing a nanofiltration, a cation exchange, an anion exchange, or an activated carbon purification.

34 . The plant of claim 32 comprising a cooling crystallizer disposed downstream of the acidification unit.

Assignees

• Thyssenkrupp Ind Solutions Ag
• Thyssenkrupp Ag

Inventors

• Schütze Joachim
• Braun Gerd

Classifications

• C07C51/47

  by solid-liquid treatment; by chemisorption · CPC title

• C07C51/43 Primary

  by change of the physical state, e.g. crystallisation · CPC title

• C07D233/64

  with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine · CPC title

• C07C319/28

  Separation; Purification · CPC title

• B01D61/027

  Nanofiltration · CPC title