Compounds and methods for treatment of viral infections

Patent metadata

Field	Value
Publication number	US-11780844-B2
Application number	US-202318117858-A
Country	US
Kind code	B2
Filing date	Mar 6, 2023
Priority date	Mar 2, 2022
Publication date	Oct 10, 2023
Grant date	Oct 10, 2023

Abstract

Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

First claim

The invention claimed is:

1. A compound of Formula:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

3. The pharmaceutical composition of claim 2 , wherein the pharmaceutical formulation is for oral administration.

4. A compound of Formula:

5. A pharmaceutical composition comprising the compound of claim 4 and one or more pharmaceutically acceptable excipients.

6. The pharmaceutical composition of claim 5 , wherein the pharmaceutical formulation is for oral administration.

Assignees

• Gilead Sciences Inc

Inventors

• Bartlett Mark J
• Byun Daniel H
• Deng Yifan
• Cosman Ellis Jennifer L
• Kalla Rao V
• Mackman Richard L
• Siegel Dustin S
• Zeng Xianhuang

Classifications

• C07F9/6561

  containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings · CPC title

• A61P31/16

  for influenza or rhinoviruses · CPC title

• A61P31/14 Primary

  for RNA viruses · CPC title

• A61P31/12

  Antivirals · CPC title

• A61K31/53

  having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine (melarsoprol A61K31/555 {; with four nitrogen atoms A61K31/495}) · CPC title