Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system

Patent metadata

Field	Value
Publication number	US-11773363-B2
Application number	US-202218073835-A
Country	US
Kind code	B2
Filing date	Dec 2, 2022
Priority date	Oct 8, 2010
Publication date	Oct 3, 2023
Grant date	Oct 3, 2023

Abstract

Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.

First claim

What is claimed is:

1. A method for configuring a protocol for cell expansion, the method comprising:
receiving, via a user interface of a display device, an indication to configure a process for cell expansion; and
in response to receiving the indication, displaying a diagram view of a cell expansion system on the user interface of the display device, wherein displaying the diagram view includes:
depicting a first space of a bioreactor of the cell expansion system on the user interface of the display device; and
depicting a first direction of a first fluid flow in the first space of the bioreactor with a first visual indicia.

2. The method of claim 1 , wherein the bioreactor comprises a hollow fiber membrane.

3. The method of claim 1 , wherein the cell expansion system is a closed cell expansion system.

4. The method of claim 1 , wherein the first space comprises an intracapillary space of the bioreactor.

5. The method of claim 1 , wherein the first space comprises an extracapillary space of the bioreactor.

6. The method of claim 1 , further comprising:
depicting a second space of the bioreactor on the user interface of the display device; and
depicting a second direction of a second fluid flow in the second space of the bioreactor with a second visual indicia.

7. The method of claim 1 , further comprising:
receiving a touch event on a portion of the user interface;
determining a location of the touch event on the display device; and
mapping the location of the touch event to a first graphical user interface (GUI) element displayed on the user interface.

8. The method of claim 7 , further comprising:
determining whether the first GUI element is associated with a menu of options; and
in response to a determination that the first GUI element is associated with the menu of options, displaying the menu of options in the diagram view.

9. The method of claim 7 , further comprising:
determining whether the first GUI element is associated with a numeric value;
in response to a determination that the first GUI element is associated with the numeric value, displaying a data entry pad in the diagram view to receive a first value for a setting of the process for cell expansion, and receiving the first value at the data entry pad; and
in response to receiving an indication to execute the process for cell expansion, executing the process for cell expansion using the first value for the setting.

10. A display device for configuring a protocol for cell expansion, the display device comprising:
at least one processor;
a display in communication with the at least one processor, the display configured to display a user interface; and
memory in communication with the at least one processor, the memory configured to store computer-executable instructions that, when executed by the processor, cause the at least one processor to:
receive, via the user interface of the display, an indication to configure a process for cell expansion; and
in response to receiving the indication, display a diagram view of a cell expansion system on the user interface of the display, wherein displaying the diagram view includes:
depicting a first space of a bioreactor of the cell expansion system on the user interface of the display; and
depicting a first direction of a first fluid flow in the first space of the bioreactor with a first visual indicia.

11. The display device of claim 10 , wherein the bioreactor comprises a hollow fiber membrane.

12. The display device of claim 10 , wherein the cell expansion system is a closed cell expansion system.

13. The display device of claim 10 , wherein the first space comprises an intracapillary space of the bioreactor.

14. The display device of claim 10 , wherein the first space comprises an extracapillary space of the bioreactor.

15. The display device of claim 10 , further comprising:
depicting a second space of the bioreactor on the user interface of the display device; and
depicting a second direction of a second fluid flow in the second space of the bioreactor with a second visual indicia.

16. A cell expansion system, the system comprising:
a bioreactor;
at least one processor;
a display device in communication with the at least one processor, the display device configured to display a user interface; and
memory in communication with the at least one processor, the memory configured to store computer-executable instructions that, when executed by the processor, cause the at least one processor to:
display a rocker setting graphical user interface (GUI) element on the user interface of the display device, the rocker setting GUI element configured to determine a position and movement of the bioreactor during a process for cell expansion;
receive, via the user interface of the display, a setting selection of the rocker setting GUI element; and
control the position and movement of the bioreactor during the process for cell expansion, according to the setting selection of the rocker setting GUI element.

17. The system of claim 16 , wherein:
the setting selection includes a stationary setting selection of the rocker setting GUI element; and
controlling the position and movement of the bioreactor includes maintaining the bioreactor in a stationary position during at least a portion of the process for cell expansion.

18. The system of claim 16 , wherein:
the setting selection includes a motion setting selection of the rocker setting GUI element; and
controlling the position and movement of the bioreactor includes:
determining a degree of motion of clockwise or counter-clockwise movement according to the motion setting selection of the rocker setting GUI element, the rocker setting GUI element configured to facilitate selection of a specified range of degrees of clockwise or counter-clockwise movement; and
controlling the bioreactor to move the degree of motion of clockwise or counterclockwise movement specified by the motion setting selection of the rocker setting GUI element.

19. The system of claim 16 , wherein:
the setting selection includes a dwell time setting selection of the rocker setting GUI element; and
controlling the position and movement of the bioreactor includes:
determining an amount of time for the system to rest at start and end positions, according to dwell time setting selection of the rocker setting GUI element; and
controlling the bioreactor to rest at start and end positions for the amount of time specified by the dwell time setting selection of the rocker setting GUI element.

20. The system of claim 16 , computer-executable instructions, when executed by the processor, cause the at least one processor to:
display a stop condition GUI element on the user interface of the display device;
receive a stop condition setting input via the stop condition GUI element; and
control stopping of at least one step or task of the process for cell expansion according to the stop condition setting, wherein the stop condition setting includes at least one of a manual stop condition, a time stop condition, an intracapillary volume stop condition, an extracapillary volume stop condition, an exchange stop condition, and an empty air removal chamber (ARC) stop condition.

Assignees

• Terumo Bct Inc

Inventors

• Stanton Iv Edward Allan
• Antwiler Glen Delbert
• Howley Patrick J
• Kinzie Michael E
• Dodd Jon A
• Medina Casey V

Classifications

• C12M41/44 Primary

  of volume or liquid level · CPC title

• C12M23/42

  Integrated assemblies, e.g. cassettes or cartridges · CPC title

• C12M23/44

  Multiple separable units; Modules · CPC title

• C12M25/10

  Hollow fibers or tubes (hollow fiber modules in general B01D63/02) · CPC title

• C12M25/12

  the culture medium flowing outside the fiber or tube · CPC title