Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system

Patent metadata

Field	Value
Publication number	US-9725689-B2
Application number	US-201113269323-A
Country	US
Kind code	B2
Filing date	Oct 7, 2011
Priority date	Oct 8, 2010
Publication date	Aug 8, 2017
Grant date	Aug 8, 2017

Abstract

Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.

First claim

What is claimed is:

1. A processor-implemented method for configuring a protocol for cell expansion, wherein a processor performs the method comprising:
providing a user interface for receiving a configuration of the protocol for use with a closed cell expansion system, wherein the closed cell expansion system comprises a hollow fiber bioreactor, and wherein the hollow fiber bioreactor comprises an intracapillary space and an extracapillary space;
receiving a first selection through the user interface to configure the protocol;
determining a first process and a second process associated with the protocol;
providing, in a table view, data associated with one or more settings stored in association with the first process;
receiving a second selection to configure the first process;
determining one or more settings associated with the first process;
determining a first setting of the one or more settings is configurable;
providing a diagram view of the closed cell expansion system for configuring the first process, comprising:
associating the diagram view with the first process;
depicting the intracapillary space of the hollow fiber bioreactor;
depicting the extracapillary space of the hollow fiber bioreactor;
depicting, using a first visual indicator, a direction of a fluid flow in the intracapillary space and a direction of a fluid flow in the extracapillary space of the hollow fiber bioreactor;
providing the first setting as a first graphical user interface element; and
in response to determining the first setting is configurable, enabling the first graphical user interface element for selection;

receiving a third selection to configure the first setting;
determining the first setting is associated with a first numeric value;
in response to determining the first setting is associated with the first numeric value, providing a data entry pad in the diagram view to receive the first numeric value;
receiving, at the data entry pad, the first numeric value for the first setting;
displaying, in the diagram view, the received first numeric value in association with the first graphical user interface element; and
executing the protocol using the received first numeric value for the first setting.

2. The processor-implemented method as defined in claim 1 , wherein receiving the third selection to configure the first setting comprises:
receiving a touch event on a display area of the user interface of the closed cell expansion system;
determining a location of the touch event;
mapping the location of the touch event to the first graphical user interface element;
determining the first graphical user interface element is associated with the first setting of the first process; and
determining the first graphical user interface element is associated with configuring the first setting of the first process.

3. The processor-implemented method as defined in claim 1 , further comprising:
receiving an indication to store the received first numeric value for the first setting; and
storing the received first numeric value for the first setting.

4. The processor-implemented method as defined in claim 3 , further comprising:
receiving an indication to execute the protocol; and
retrieving the received first numeric value for the first setting.

5. The processor-implemented method as defined in claim 1 , further comprising:
determining to calculate a second numeric value for a second setting based on the received first numeric value for the first setting;
automatically calculating the second numeric value; and
displaying the second numeric value in association with a second graphical user interface element in the diagram view.

6. The processor-implemented method as defined in claim 5 , wherein the first setting comprises an inlet rate, and wherein the second setting comprises a circulation rate.

7. The processor-implemented method as defined in claim 5 , further comprising:
indicating, in the diagram view, that the second setting is not configurable.

8. The processor-implemented method as defined in claim 1 , wherein the enabling the first graphical user interface element for selection comprises:
associating a second visual indicator with the first graphical user interface element; and
in response to determining the first setting is configurable, associating a third visual indicator with the first graphical user interface element.

9. A closed cell expansion system, the system comprising:
a processor;
a display device, in communication with the processor, operable to display data; and
a memory, in communication with and readable by the processor, and containing a series of instructions that, when executed by the processor, cause the processor to:
receive first data to configure a display setting;
store the first data in association with the display setting;
receive second data to configure a system setting;
store the second data in association with the system setting;
receive a first selection to configure a task for use with the closed cell expansion system, wherein the closed cell expansion system comprises a hollow fiber bioreactor, wherein the hollow fiber bioreactor comprises an intracapillary space and an extracapillary space, and wherein the task comprises one or more steps;
receive a second selection to configure a first step of the one or more steps;
retrieve one or more settings associated with the first step;
determine a first setting of the one or more settings is configurable;
provide a diagram view of the closed cell expansion system for configuring the first step, comprising:
associate the diagram view with the first step;
depict the intracapillary space of the hollow fiber bioreactor;
depict the extracapillary space of the hollow fiber bioreactor;
depict, using a first visual indicator, a direction of a fluid flow in the intracapillary space and a direction of a fluid flow in the extracapillary space of the hollow fiber bioreactor;
provide the first setting as a first graphical user interface element; and
in response to determining the first setting is configurable, enable the first graphical user interface element for selection;

receive a third selection to configure the first setting;
determine the first setting is associated with one or more pre-defined selection options;
in response to determining the first setting is associated with the one or more pre-defined selection options, provide a list of the one or more pre-defined selection options in the diagram view;
receive a fourth selection from the list of the one or more pre-defined selection options;
display, in the diagram view, a selected pre-defined selection option in association with the first graphical user interface element; and
execute the task using the selected pre-defined selection option for the first setting.

10. The closed cell expansion system of claim 9 , wherein the enabling of the first graphical user interface element for selection comprises:
associate a second visual indicator with the first graphical user interface element; and
in response to determining the first setting is configurable, associate a third visual indicator with the first graphical user interface element.

11. The closed cell expansion system of claim 9 , wherein the display setting comprises a language for use in displaying text.

12. The closed cell expansion system of claim 9 , wherein the system setting comprises a low-temperature alarm.

13. A non-transitory processor-readable storage medium storing executable instructions which, when executed by a processor, perform a method of configuring a closed cell expansion system, the

Assignees

• Stanton Iv Edward Allan
• Antwiler Glen Delbert
• Howley Patrick J
• Kinzie Michael E
• Dodd Jon A
• Medina Casey V
• Terumo Bct Inc

Inventors

• Stanton Iv Edward Allan
• Antwiler Glen Delbert
• Howley Patrick J
• Kinzie Michael E
• Dodd Jon A
• Medina Casey V

Classifications

• C12M41/48

  Automatic or computerized control (automatic analysis G01N35/00) · CPC title

• C12M23/42

  Integrated assemblies, e.g. cassettes or cartridges · CPC title

• G06F8/38

  for implementing user interfaces · CPC title

• C12M25/12

  the culture medium flowing outside the fiber or tube · CPC title

• C12M23/44

  Multiple separable units; Modules · CPC title