Compositions and methods related to 2 dimensional molecular composites

Patent metadata

Field	Value
Publication number	US-11739164-B2
Application number	US-201716463158-A
Country	US
Kind code	B2
Filing date	Dec 14, 2017
Priority date	Dec 14, 2016
Publication date	Aug 29, 2023
Grant date	Aug 29, 2023

Abstract

Provided are compositions that include at least one two-dimensional layer of an inorganic compound and at least one layer of an organic compound in the form of one or more polypeptides. Methods of making and using the materials are provided. The organic layer contains one or more polypeptides, each of which have alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming subsequences form crystallites comprising stacks of one or more beta-sheets. The amorphous subsequences form a network of hydrogen bonds. A method includes i) combining one or more polypeptides with an inorganic material and an organic solvent, and ii) depositing one or more polypeptides, the inorganic material and the organic solvent onto a substrate. These steps can be repeated to provide a composite material that is a multilayer composite material. The composite materials can be used in a wide array of textile, electronic, semi-conducting, and other applications.

First claim

What is claimed is:

1. A method of making a composite material comprising at least one two-dimensional (2D) inorganic layer comprising two-dimensional titanium carbide (MXene) and an at least one organic layer, the organic layer comprising one or more polypeptides which comprise alternating repeats of crystallite-forming subsequences and amorphous subsequences, wherein the crystallite-forming subsequences form crystallites comprising stacks of one or more β-sheets, and wherein the amorphous subsequences form a network of hydrogen bonds, the method comprising i) combining the one or more polypeptides with an inorganic material and an organic solvent, and ii) depositing the one or more polypeptides, the inorganic material and the organic solvent onto a substrate, thereby forming at least one composite layer comprising the one or more polypeptides and the inorganic material, and optionally repeating i) and ii) to form the composite material that is a multilayer composite material.

2. The method of claim 1 , wherein the at least one organic layer has a thickness of from 0.5 nm-10.0 nm.

3. The method of claim 1 , wherein the at least one inorganic layer has a thickness of from 0.5 nm-10.0 nm.

4. The method of claim 1 , wherein the crystallite-forming subsequence is from about 2 nm to about 5 nm long.

5. The method of claim 1 , wherein the one or more polypeptides comprises from 4 to 20 repeats of the crystallite-forming subsequences.

6. The method of claim 1 , wherein the one or more polypeptide comprises from 4 to 20 repeats of the crystallite-forming subsequences.

7. The method of claim 1 , wherein the one or more polypeptides comprises a sequence that exhibits crystallinity between 0% and 60%.

8. The method of claim 1 , wherein the amorphous subsequence comprises from 10 to 60 amino acids.

9. The method of claim 1 , comprising forming the multilayer composite material, wherein the multilayer composite material comprises between 2 and 10 9 composite layers, each of which composite layers comprises an organic layer and an inorganic layer.

10. The method of claim 1 , wherein the depositing the one or more polypeptides, the inorganic layer and the organic solvent onto the substrate comprises vacuum assisted self-assembly, or by passing the one or more polypeptides, the inorganic material and the organic solvent through a nozzle onto the substrate, wherein the composite material optionally comprises a heterostructure.

11. The method of claim 10 , comprising the passing through the nozzle, wherein the one or more polypeptides, the inorganic material and the organic solvent are in a droplet having a diameter of from 50 to 70 μm.

12. The method of claim 10 , wherein the one or more polypeptides, the inorganic material and the organic solvent are placed on the substrate to form lines having a minimum distance between one another of not less than 40 μm.

13. The method of claim 10 , wherein the composite material consists essentially of the one or more polypeptides and the inorganic material.

14. The method of claim 10 , comprising the passing through the nozzle.

15. The method of claim 14 , wherein the passing through the nozzle comprises inkjet printing onto the substrate.

16. The method of claim 15 , wherein the one or more polypeptides, the inorganic material and the organic solvent are in a droplet having a diameter of from 50 to 70 μm, and wherein the one or more polypeptides, the inorganic material and the organic solvent are placed on the substrate to form lines having a minimum distance between one another of not less than 40 μm.

17. A composite material made by a method of claim 10 .

18. A composite material made by a method of claim 15 .

19. A composite material made by a method of claim 16 .

20. A method of making a composite material as in claim 10 , comprising selecting a crystallite-forming subsequence and selecting an amorphous subsequence, the crystallite-forming subsequence comprising amino acid sequences that are capable of forming the crystallite-forming subsequences, wherein the crystallite-forming subsequences are from about 2 nm to about 5 nm long and comprise from 10 to 30 amino acids, and selecting an amino acid sequence that is capable of forming the amorphous subsequence, wherein the amorphous subsequence is about 3 nm long and comprise about 15 amino acids, and forming the composite material by incorporating an amino acid sequence that is capable of forming the crystallite-forming subsequences and an amino acid sequence that is capable of forming the an amorphous subsequence into a synthetic or recombinant polypeptide, and mixing the synthetic or recombinant polypeptide with an inorganic material that is two-dimensional titanium carbide (MXene) or a combination of the MXene and graphite oxide, and an organic solvent, and depositing the synthetic or recombinant polypeptide, the inorganic material and the organic solvent onto a substrate.

21. The method of claim 20 , wherein the depositing onto the substrate comprises depositing the synthetic or recombinant polypeptide, the inorganic layer and the organic solvent onto the substrate comprises vacuum assisted self-assembly, or by passing the one or more polypeptides, the inorganic material and the organic solvent through a nozzle onto the substrate.

Assignees

• Penn State Res Found

Inventors

• Demirel Melik
• Vural Mert
• Terrones Mauricio
• Lei Yu
• Ozbolat Ibrahim Tarik

Classifications

• C07K17/14 Primary

  Peptides being immobilised on, or in, an inorganic carrier · CPC title

• B41M5/0011

  Pre-treatment or treatment during printing of the recording material, e.g. heating, irradiating (after-treatment of prints B41M7/00; printers for treating or overcoating copy materials before, during or after printing B41J11/0015) · CPC title

• C07K1/042

  characterised by the nature of the carrier · CPC title

• B82Y15/00

  Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors · CPC title

• B82Y40/00

  Manufacture or treatment of nanostructures · CPC title