Peptide capable of silica deposition and use thereof

Patent metadata

Field	Value
Publication number	US-2016376575-A1
Application number	US-201615194712-A
Country	US
Kind code	A1
Filing date	Jun 28, 2016
Priority date	Sep 30, 2011
Publication date	Dec 29, 2016
Grant date	—

Abstract

A peptide for synthesizing silica and use thereof are provided. The peptide for synthesizing silica can polymerize silica from a silica precursor in an aqueous solution having conditions of normal temperature, normal pressure and near-neutral weak base. The peptide for synthesizing silica can form a self-assembled structure during silica synthesis, and thus can be used as various biomaterials such as a silica-based protein immobilizer, a biosensor, and a drug delivery system.

First claim

What is claimed is:

1 . A fusion protein comprising:
at least one peptide selected from the group consisting of amino acid sequences set forth in SEQ ID NOs: 1 to 10; and a self-assembling protein.

2 . The fusion protein of claim 1 , wherein the self-assembling protein is a ferritin or a viral capsid protein.

3 . A composition for synthesizing silica, comprising the fusion protein of claim 1 .

4 . A silica complex in which surfaces of self-assembled structures of at least one peptide selected from the group consisting of amino acid sequences set forth in SEQ ID NOs: 1 to 10, and a self-assembling protein are coated with silica.

5 . A drug delivery system comprising:
the silica complex of claim 4 ; and a pharmaceutically acceptable carrier.

6 . A contrast agent composition comprising:
the silica complex of claim 4 ; and a pharmaceutically acceptable carrier.

7 . A target-directed contrast agent composition comprising:
the silica complex of claim 4 ; and a pharmaceutically acceptable carrier.

8 . A contrast agent composition for simultaneous diagnosis or treatment, comprising:
the silica complex of claim 4 ; and a pharmaceutically acceptable carrier.

9 . A multi-diagnostic probe comprising:
the silica complex of claim 4 ; and a diagnostic probe.

10 . A fiber into which the silica complex of claim 4 is electrospun.

11 . A filter comprising the fiber into which the silica complex of claim 4 is electrospun.

12 . A bone substitute comprising the silica complex of claim 4 .

13 . A photonic device comprising the silica complex of claim 4 .

14 . A biosensor for detecting a biomolecule, comprising the silica complex of claim 4 .

15 . The biosensor of claim 14 , wherein the biomolecule is a nucleic acid, a protein, a polysaccharide, or a pathogen.

Assignees

• Univ Korea Res & Bus Found

Inventors

• Pack Seung Pil
• Ki Mi Ran

Classifications

• C07K14/00

  Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof · CPC title

• C12Y207/01

  Phosphotransferases with an alcohol group as acceptor (2.7.1) · CPC title

• A61K49/00

  Preparations for testing in vivo · CPC title

• C07K2319/735

  containing a domain for self-assembly, e.g. a viral coat protein (includes phage display) · CPC title

• C07K17/14

  Peptides being immobilised on, or in, an inorganic carrier · CPC title