Macrocyclic compound and uses thereof
US-9938288-B1 · Apr 10, 2018 · US
US11725015B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11725015-B2 |
| Application number | US-202117167480-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 4, 2021 |
| Priority date | Apr 5, 2017 |
| Publication date | Aug 15, 2023 |
| Grant date | Aug 15, 2023 |
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The present invention provides novel Compound (1) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, and medical uses thereof.
Opening claim text (preview).
What is claimed is: 1. A compound selected from the group consisting of: and salts thereof. 2. The compound of claim 1 , wherein the compound is of Formula (C-8), or a salt thereof. 3. The compound of claim 1 , wherein the compound is of the formula: or a salt thereof. 4. The compound of claim 1 , wherein the compound is of Formula (C-7), or a salt thereof. 5. The compound of claim 1 , wherein the compound is of Formula (C-6), or a salt thereof. 6. The compound of claim 1 , wherein the compound is of Formula (C-5), or a salt thereof. 7. The compound of claim 1 , wherein the compound is of Formula (C-4), or a salt thereof. 8. The compound of claim 1 , wherein the compound is of Formula (C-3), or a salt thereof.
having six-membered rings with one oxygen as the only ring hetero atom · CPC title
Antineoplastic agents · CPC title
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms · CPC title
in which the condensed system contains four or more hetero rings · CPC title
having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel · CPC title
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