Halichondrin B analogs
US-9206194-B2 · Dec 8, 2015 · US
Halichondrin B analogs
US9469651B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9469651-B2 |
| Application number | US-201514707763-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 8, 2015 |
| Priority date | Apr 4, 2008 |
| Publication date | Oct 18, 2016 |
| Grant date | Oct 18, 2016 |
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- Title
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Abstract
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The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediates.
First claim
Opening claim text (preview).
The claimed invention is: 1. A crystalline monohydrate of the compound: wherein the crystalline monohydrate comprises less than 0.1 wt % of its C25 epimer and is characterized by a powder x-ray diffraction pattern having peaks at 9.3 °2θ±0.2 °2θ, 10.4 °2θ±0.2 °2θ, and 13.0 °2θ±0.2 °2θ. 2. The crystalline monohydrate of claim 1 , further characterized by a differential scanning calorimetry thermogram having an endothermic peak temperature ranging from about 157 to about 161° C.
Assignees
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Classifications
- C07D493/22Primary
in which the condensed system contains four or more hetero rings · CPC title
Antineoplastic agents · CPC title
Crystalline forms, e.g. polymorphs · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
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Frequently asked questions
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- What does patent US9469651B2 cover?
- The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediates.
- Who is the assignee on this patent?
- Eisai R&D Man Co Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07D493/22. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 18 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 9 related publications on this page (citations in our corpus or others sharing the same primary CPC).