Bioreactor including a rocking device

Patent metadata

Field	Value
Publication number	US-11613726-B2
Application number	US-201715653501-A
Country	US
Kind code	B2
Filing date	Jul 18, 2017
Priority date	Feb 23, 2011
Publication date	Mar 28, 2023
Grant date	Mar 28, 2023

Abstract

The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray ( 4 ) for holding said at least one bag, a rocking device for limited rocking motions of the tray ( 4 ) around a rocking axis ( 2 ). According to the invention the bioreactor comprises a device ( 6,7,8,9 ) for enabling swinging of the tray ( 4 ) around a second axis ( 7 ) parallel to and distanced from the rocking axis ( 2 ).

First claim

What is claimed is:

1. A device for use with a bioreactor, the device comprising:
a base;
a platform having a first end and a second end and being operably connected to the base, the operable connection providing a rocking motion such that the first and second ends alternately rock up and away from the base;
wherein, the platform first end and the base form a first pivot axis associated with a first angle defined between the base and the platform along the first pivot axis;
a tray being pivotally connected to the platform second end, the pivotal connection forming a second pivot axis associated with a second angle defined between the tray and the platform second end along the second pivot axis; and
at least one gas spring damper longitudinally extending between the platform and the tray, a first end of the at least one gas spring damper being coupled to the tray and a second end of the at least one gas spring damper being coupled to the platform,
wherein pivoting of the platform first end about the first pivot axis up and away from the base changes the first angle, and pivoting of the tray about the second pivot axis up and away from the platform changes the second angle, the changes in the first and second angles occurring cooperatively to facilitate extension of the tray from an operating position parallel to the platform to an upright release position,
wherein the length of the at least one gas spring damper, a position of the first end of the at least one gas spring damper along the tray, and a position of the second end of the at least one gas spring damper along the platform provides a sum of the first angle and the second angle from 60° to 90° in the upright release position.

2. The device of claim 1 , further comprising one of a set of spring dampers for releasably locking the tray in set positions.

3. The device of claim 1 , further comprising a hinge connection located at a distance from a first axis and to which one end of at least one gas spring damper is pivotally attached.

4. The device of claim 1 , wherein the tray is pivotable around a rotation axis being perpendicular to a plane of the tray.

5. The device of claim 1 , further comprising at least one reactor vessel retainably clamped to the tray in the operating position and in the upright release position.

6. The device of claim 1 , wherein the second axis further enables the platform first end and the platform second end to pivot between an angle of +alpha and an angle of -alpha with respect to a horizontal line.

7. The device of claim 1 , wherein the first axis and second axis together enable the tray to extend upright at an angle of about 72 degrees with respect to a horizontal line.

Assignees

• Cytiva Sweden Ab

Inventors

• Andersson Andreas
• Carlsson Lars Johan
• Elnegard Christian
• Eriksson Henrik K
• Falkman Thomas
• Fricking Patric
• Pauler Linnea
• Peterson Claes

Classifications

• C12M23/14

  Bags · CPC title

• C12M23/50

  Means for positioning or orientating the apparatus (C12M41/08 takes precedence) · CPC title

• B01F35/513

  Flexible receptacles, e.g. bags supported by rigid containers · CPC title

• B01F31/23

  by pivoting the containers about an axis · CPC title

• C12M27/16 Primary

  Vibrating; Shaking; Tilting · CPC title