Aipa, ompa, and asp14 in vaccine compositions and diagnostic targets for anaplasma phagocytophilum infection
US-2018369354-A1 · Dec 27, 2018 · US
AipA, OmpA, and Asp14 in vaccine compositions and diagnostic targets for Anaplasma phagocytophilum infection
US11458197B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11458197-B2 |
| Application number | US-202017071385-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 15, 2020 |
| Priority date | Feb 3, 2014 |
| Publication date | Oct 4, 2022 |
| Grant date | Oct 4, 2022 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
Anaplasma phagocytophilum surface protein AipA and/or fragments thereof which comprise an invasin domain are used in compositions suitable to elicit an immune response to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. AipA proteins and protein fragments or antibodies directed to AipA proteins and protein fragments are also used in diagnostic assays to detect exposure to and/or infection with Anaplasmatacaea. AipA and/or fragments thereof are also used for these purposes in combination with one or both of Asp14 and OmpA proteins and/or fragments thereof which comprise an invasin domain. Homologs of these proteins are also used in the compositions and assays.
First claim
Opening claim text (preview).
We claim: 1. A chimeric protein comprising a polypeptide that is or includes one or more copies of SEQ ID NO:14 and one or more polypeptide sequences that differ from SEQ ID NO: 14. 2. The chimeric protein of claim 1 , wherein said one or more polypeptide sequences is or includes one or more copies of at least one of SEQ ID NO:03 and SEQ ID NO:06. 3. The chimeric protein of claim 1 , wherein the one or more polypeptide sequences is or includes one or more of: an amino acid spacer, an amino acid linker, a signal sequence, a stop transfer sequence, a transmembrane domain, a protein purification ligand, a heterologous protein, SEQ ID NO:01, SEQ ID NO:02, SEQ ID NO:03, SEQ ID NO:04, SEQ ID NO:05, SEQ ID NO:06, SEQ ID NO:07, SEQ ID NO:08, SEQ ID NO:09, SEQ ID NO:13 and SEQ ID NO:15.
Assignees
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Classifications
from Richettsiales (O) · CPC title
containing a transmembrane segment · CPC title
containing a GST-tag · CPC title
Fusion polypeptide · CPC title
Bacteria · CPC title
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- What does patent US11458197B2 cover?
- Anaplasma phagocytophilum surface protein AipA and/or fragments thereof which comprise an invasin domain are used in compositions suitable to elicit an immune response to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. AipA proteins and protein fragments or antibodies directed to AipA proteins and protein fragments are also used in diagnostic assays to de…
- Who is the assignee on this patent?
- Univ Virginia Commonwealth
- What technology area does this patent fall under?
- Primary CPC classification A61K39/0233. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 04 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).