Bioreactor systems with tube supports

Patent metadata

Field	Value
Publication number	US-11358107-B2
Application number	US-201816196882-A
Country	US
Kind code	B2
Filing date	Nov 20, 2018
Priority date	Jun 16, 2010
Publication date	Jun 14, 2022
Grant date	Jun 14, 2022

Abstract

A bioreactor system includes a support housing having an interior surface bounding a compartment. A rack is secured to the support housing in alignment with the opening. An elongated first shaft has a first end and an opposing second end, the first end of the first shaft being secured to the rack. A structure is secured to the first shaft at or towards the second end of the first shaft, the structure outwardly projecting away from the first shaft. A collapsible bag bounds a chamber and is at least partially disposed within the compartment of the support housing. A member projects from the collapsible bag and passes through the opening on the support housing, the structure supporting or restraining movement of the member.

First claim

What is claimed is:

1. A bioreactor system comprising:
a support housing having a floor and a sidewall upstanding from the floor and encircling a compartment, the sidewall terminating at an upper end that encircles an upper opening communicating with the compartment, a side opening extends laterally through the sidewall between an interior surface and an exterior surface of the sidewall so as to communicate with the compartment, the side opening being disposed between the upper opening and the floor;
a rack secured to the support housing outside of the compartment, the rack being disposed between the upper opening and the floor of the support housing so as to be spaced apart from the upper opening;
an elongated first shaft having a first end and an opposing second end, the first shaft being secured to the rack;
a structure secured to the first shaft;
a collapsible bag bounding a chamber, the collapsible bag being at least partially disposed within the compartment of the support housing and resting on the floor of the support housing; and
a tubular member projecting from the collapsible bag and passing through the side opening on the support housing, the structure at least partially encircling the tubular member.

2. The bioreactor system as recited in claim 1 , wherein the structure is secured at or toward the second end of the first shaft, the structure outwardly projecting away from the first shaft.

3. The bioreactor system as recited in claim 1 , wherein the structure has a bend.

4. The bioreactor system as recited in claim 1 , wherein the structure is resiliently flexible.

5. The bioreactor system as recited in claim 1 , wherein the rack is at least partially disposed within the side opening of the support housing.

6. The bioreactor system as recited in claim 1 , wherein the rack is horizontally aligned with the side opening of the support housing.

7. The bioreactor system as recited in claim 1 , wherein first end of the first shaft is removably secured to the rack and the structure is secured to the second end of the first shaft.

8. The bioreactor system as recited in claim 1 , wherein the rack comprises a flat plate.

9. The bioreactor system as recited in claim 1 , wherein the sidewall of the support housing comprises a movable door, the door at least partially bounding the side opening.

10. The bioreactor system as recited in claim 1 , wherein the tubular member comprises a tube.

11. The bioreactor system as recited in claim 1 , further comprising a rotatable impeller disposed within the chamber of the collapsible bag.

12. The bioreactor system as recited in claim 1 , further comprising an elongated second shaft having a first end and an opposing second end, the second shaft being secured to the rack at a location spaced apart from the first shaft.

13. The bioreactor system as recited in claim 1 , wherein the rack is disposed entirely outside of the compartment of the support housing.

14. A bioreactor system comprising:
a support housing having a floor and a sidewall upstanding from the floor and encircling a compartment, the sidewall terminating at an upper end that encircles an upper opening communicating with the compartment, a side opening extends laterally through the sidewall between an interior surface and an exterior surface of the sidewall so as to communicate with the compartment, the side opening being disposed between the upper opening and the floor;
a rack secured to the support housing outside of the compartment, the rack disposed between the upper opening and the floor of the support housing so as to be spaced apart from the upper opening;
a structure secured to the rack;
a collapsible bag bounding a chamber, the collapsible bag being at least partially disposed within the compartment of the support housing and resting on the floor of the support housing; and
a tubular member projecting from the collapsible bag and passing through the side opening of the support housing, the structure at least partially encircling the tubular member.

15. The bioreactor system as recited in claim 14 , wherein the structure has a curve.

16. The bioreactor system as recited in claim 14 , wherein the rack is at least partially disposed within the side opening of the support housing.

17. The bioreactor system as recited in claim 14 , wherein the rack comprises a flat plate.

18. The bioreactor system as recited in claim 14 , wherein the tubular member comprises a tube.

19. The bioreactor system as recited in claim 14 , wherein the rack is U-shaped.

20. The bioreactor system as recited in claim 14 , wherein the structure is a clamp.

21. The bioreactor system as recited in claim 1 , wherein the structure is a clamp.

22. The bioreactor system as recited in claim 10 , wherein the tubular member further comprises a tubular port extending between the bag and the tube.

23. The bioreactor system as recited in claim 1 , wherein the structure is disposed directly against the tubular member.

Assignees

• Life Technologies Corp

Inventors

• Goodwin Michael E
• Cornia Wade A
• Lee Jacob D

Classifications

• B01F35/513

  Flexible receptacles, e.g. bags supported by rigid containers · CPC title

• B01F2101/22

  Mixing of ingredients for pharmaceutical or medical compositions · CPC title

• B01F27/113

  Propeller-shaped stirrers for producing an axial flow, e.g. shaped like a ship or aircraft propeller · CPC title

• B01F27/213

  characterised by the connection with the drive · CPC title

• B01F27/2121 Primary

  composed of interconnected parts · CPC title