Drug delivery device

Patent metadata

Field	Value
Publication number	US-11344681-B2
Application number	US-201615047835-A
Country	US
Kind code	B2
Filing date	Feb 19, 2016
Priority date	Nov 21, 2012
Publication date	May 31, 2022
Grant date	May 31, 2022

Abstract

A drug delivery device includes a blunt cannula and a reservoir. The blunt cannula has a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula. The wall has at least a first tapered region at the first end to define an opening in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula. The reservoir is connected to the second end of the blunt cannula.

First claim

We claim:

1. A wearable on-body drug delivery device comprising:
a housing having an opening;
an adhesive layer attached to a surface of the housing for attaching the drug delivery device to a patient's skin;
a reservoir disposed in the housing, the reservoir including a barrel;
a plunger movably disposed in the barrel;
a volume of a drug product disposed in the reservoir, the drug product comprising a granulocyte colony-stimulating factor (G-CSF);
a first needle;
a cannula or second needle having a cylindrical wall that defines an axial passage between a first end and a second end of the cannula or second needle, the first end of the cannula or second needle being initially retracted within the housing and subsequently deployed through the opening in the housing for insertion into the patient's skin, the second end of the cannula or second needle configured to be operably connected in fluid communication with the reservoir via the first needle, wherein the first needle does not penetrate the patient's skin during insertion of the first end of the cannula or second needle into the patient's skin;
a drive operably coupled to the reservoir to urge the drug product from the reservoir, through the cannula or second needle, and to a patient during use of the drug delivery device; and
wherein the wearable on-body drug delivery device is free of an introducer needle for introducing the cannula or second needle into the patient's skin.

2. The drug delivery device according to claim 1 , wherein the cannula or second needle has at least one side port formed in the wall of the cannula or second needle at the first end.

3. The drug delivery device according to claim 2 , wherein the at least one side port comprises a pair of side ports.

4. The drug delivery device according to claim 3 , wherein the pair of side ports are aligned with each other across the axial passage.

5. The drug delivery device according to claim 2 , wherein the at least one side port comprises a circular opening formed in the wall to permit flow transverse to the axial passage.

6. The drug delivery device according to claim 2 , wherein the at least one side port comprises an elongated slit formed in the wall to permit flow transverse to the axial passage.

7. The drug delivery device according to claim 2 , wherein the at least one side port comprises an elongated slot formed in the wall to permit flow transverse to the axial passage.

8. The drug delivery device according to claim 2 , wherein the first end of the cannula or second needle includes a first tapered region, and wherein the at least one side port is formed in the first end of the cannula or second needle distal from the first tapered region.

9. The drug delivery device according to claim 1 , wherein the first end of the cannula or second needle includes a first tapered region that comprises at least one bevel.

10. The drug delivery device according to claim 9 , wherein the first tapered region comprises only one bevel.

11. The drug delivery device according to claim 9 , wherein the first tapered region comprises two bevels intersecting each other.

12. The drug delivery device according to claim 9 , wherein the first tapered region comprises two negative or inverted bevels intersecting each other.

13. The drug delivery device according to claim 9 , wherein the first end of the cannula or second needle includes a pattern of openings disposed about an opening in the first tapered region.

14. The drug delivery device according to claim 13 , wherein the pattern of openings comprises a pattern of recesses into the wall.

15. The drug delivery device according to claim 1 , wherein the cannula or second needle has at least one external recessed region recessed toward the axial passage relative to adjoining surface regions.

16. The drug delivery device according to claim 15 , wherein the at least one external recessed region is defined by a pattern of ribs.

17. The drug delivery device according to claim 15 , wherein the at least one external recessed surface region is defined by a pattern of grooves.

18. The drug delivery device of claim 1 , comprising a hub surrounding at least a portion of the first needle.

19. The drug delivery device of claim 18 , wherein the hub is positioned adjacent to the second end of the cannula or second needle.

Assignees

• Amgen Inc

Inventors

• Ring Lawrence S
• Mehta Dhairya
• Toy Stephanie
• Tamtoro Ferry
• Cairns Alexander Stuart
• Gibson Scott R

Classifications

• A61M2025/0073

  Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow · CPC title

• A61M25/0068

  Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure · CPC title

• A61M5/20

  Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 {, A61M5/46} take precedence; {hypodermic projectiles F42B12/54}) · CPC title

• A61M5/3134

  characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula · CPC title

• A61M5/3291 Primary

  Shafts with additional lateral openings · CPC title