Mixed Bed Ion Exchange Adsorber
US-2019389901-A1 · Dec 26, 2019 · US
Chromatography media and method
US11305271B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11305271-B2 |
| Application number | US-201715677526-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 15, 2017 |
| Priority date | Jul 30, 2010 |
| Publication date | Apr 19, 2022 |
| Grant date | Apr 19, 2022 |
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- Title
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Abstract
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Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
First claim
Opening claim text (preview).
What is claimed is: 1. A process for purifying a sample containing a biomolecule and negatively charged bacteriophage phi6, comprising providing a sample containing the biomolecule and the negatively charged bacteriophage phi6; contacting said sample with an axially compressed bed of cut nylon staple fiber media, wherein said fibers have a cross-section comprising a body region defining a substantially longitudinal axis, and have a plurality of projections extending outwardly from said body region, and wherein said fibers have imparted thereon a polymeric functionality, wherein the surfaces of said polymeric functionality are modified with pendant trimethylammonium groups; washing said fibers to remove unbound species; and eluting said negatively charged bacteriophage phi6, thereby to purify said sample.
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Classifications
based on polymers · CPC title
- B01D15/361Primary
Ion-exchange · CPC title
characterised by their form or physical properties · CPC title
Peculiar structure or physical form, e.g. foam, sponge, foil, sack, bag, fiber in a matrix, monolith, microstructure, microcracking, or microaggregates · CPC title
Ion-exchange chromatography · CPC title
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- What does patent US11305271B2 cover?
- Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-excha…
- Who is the assignee on this patent?
- Emd Millipore Corp
- What technology area does this patent fall under?
- Primary CPC classification B01D15/361. Mapped technology areas include Operations & Transport.
- When was this patent published?
- Publication date Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).