Chromatography Media And Method
US-2018085743-A1 · Mar 29, 2018 · US
High surface area fiber media with nano-fibrillated surface features
US10449517B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10449517-B2 |
| Application number | US-201515323471-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 19, 2015 |
| Priority date | Sep 2, 2014 |
| Publication date | Oct 22, 2019 |
| Grant date | Oct 22, 2019 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
Chromatography media including a high surface area thermoplastic porous nanofiber and an ion-exchange ligand functionality on the surface of the fiber. The porous nanofibers display a convoluted structure that is comprised of discrete bundles of highly entangled nanofibrils that may be fibrillated or ridged. The porous fibers can be prepared through the extraction of a dissolvable mineral or polymeric porogen that is embedded into the fiber during its manufacture in a melt extrusion process.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of purifying a biomolecule in a sample, comprising contacting said sample with a bed of porous entangled nanofibers, made by a melt extrusion of a blend of polymer and porogen and drawing to a target diameter and extracting porogen therefrom, each of said porous entangled nanofibers within said bed having a diameter less than or equal to 1 micron, said porous entangled nanofibers arranged in discrete porous bundles, said porous entangled nanofibers having imparted thereon functionality enabling chromatography. 2. The method of claim 1 , wherein said biomolecule comprises a virus. 3. The method of claim 1 , wherein said functionality is grafted to said nanofibers. 4. The method of claim 1 , wherein said functionality enables purification in a bind/elute mode. 5. The method of claim 1 , wherein said polymer is a melt-processable thermoplastic polymer. 6. The method of claim 5 , wherein said melt-processable thermoplastic polymer is selected from the group consisting of polyamides, polyolefins, polyvinyl chloride, polystyrene, poly methylmethacrylate, polylactic acid, polyester, polyethylene terephthalate, polybutylene terephthalate, polyetherurethanes, polyvinyl alcohol, polyimide, polycarbonate, polyetheretherketone, polysulfone, and polytrimethylene terephthalate. 7. The method of claim 1 , wherein said polymer is nylon. 8. The method of claim 1 , wherein said porogen is a polymeric porogen. 9. The method of claim 8 , wherein said polymeric porogen is poly(lactic acid). 10. The method of claim 1 , wherein said porogen is a mineral porogen. 11. The method of claim 1 , wherein said porogen is a combination of a polymeric porogen and a mineral porogen.
Assignees
Inventors
Classifications
Affinity chromatography or related techniques based upon selective absorption processes · CPC title
Anion exchangers for chromatographic processes · CPC title
Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers · CPC title
Polymers being grafted on the carrier · CPC title
Sorbents specially adapted for preparative, analytical or investigative chromatography · CPC title
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- What does patent US10449517B2 cover?
- Chromatography media including a high surface area thermoplastic porous nanofiber and an ion-exchange ligand functionality on the surface of the fiber. The porous nanofibers display a convoluted structure that is comprised of discrete bundles of highly entangled nanofibrils that may be fibrillated or ridged. The porous fibers can be prepared through the extraction of a dissolvable mineral or po…
- Who is the assignee on this patent?
- Emd Millipore Corp
- What technology area does this patent fall under?
- Primary CPC classification B01D15/361. Mapped technology areas include Operations & Transport.
- When was this patent published?
- Publication date Tue Oct 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).