Polymer particles

Patent metadata

Field	Value
Publication number	US-11261274-B2
Application number	US-201916693077-A
Country	US
Kind code	B2
Filing date	Nov 22, 2019
Priority date	Nov 8, 2013
Publication date	Mar 1, 2022
Grant date	Mar 1, 2022

Abstract

Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.

First claim

We claim:

1. A polymer particle comprising:
a poly(ethylene glycol) diacrylamide macromer;
a first monomer; and
a second monomer configured to allow binding of positively charged drugs, wherein the second monomer is selected from acrylic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate, a salt thereof, or a combination thereof;
wherein the polymer particle is spherical.

2. The polymer particle of claim 1 , wherein the polymer particle has a diameter between about 40 μm and about 1,200 μm.

3. The polymer particle of claim 1 , wherein the polymer particle has a diameter less than about 1,200 μm.

4. The polymer particle of claim 1 , wherein the first monomer includes a functional group.

5. The polymer particle of claim 4 , wherein the functional group is an acrylate, an acrylamide, a methacrylate, or a methacrylamide.

6. The polymer particle of claim 1 , wherein the first monomer glycerol monomethacrylate, amino ethyl methacrylate, amino propyl methacrylate, or a combination thereof.

7. The polymer particle of claim 1 , wherein the poly(ethylene glycol) diacrylamide is poly(ethylene glycol) diacrylamide 10,000.

8. The polymer particle of claim 1 , wherein the poly(ethylene glycol) diacrylamide macromer is at a concentration of about 28% w/w.

9. The polymer particle of claim 1 , wherein the first monomer is amino ethyl methacrylate, amino propyl methacrylate, or a combination thereof.

10. A polymer particle comprising:
a poly(ethylene glycol) macromer,
a first monomer; and
a second monomer configured allow binding of negatively charged drugs, wherein the second monomer is selected from amino ethyl methacrylate, 2-amino ethyl methacrylate, amino propyl methacrylamide, a salt thereof, or a combination thereof;
wherein the polymer particle is spherical.

11. The polymer particle of claim 10 , wherein the polymer particle has a diameter between about 40 μm and about 1,200 μm.

12. The polymer particle of claim 10 , wherein the polymer particle has a diameter less than about 1,200 μm.

13. The polymer particle of claim 10 , wherein the first monomer includes a functional group.

14. The polymer particle of claim 13 , wherein the functional group is an acrylate, an acrylamide, a methacrylate, or a methacrylamide.

15. The polymer particle of claim 10 , wherein the first monomer is glycerol monomethacrylate, 3-sulfopropyl acrylate, or a combination thereof.

16. The polymer particle of claim 10 , wherein the poly(ethylene glycol) macromer is poly(ethylene glycol) diacrylamide.

17. The polymer particle of claim 16 , wherein the poly(ethylene glycol) diacrylamide is poly(ethylene glycol) diacrylamide 10,000.

18. The polymer particle of claim 10 , wherein the poly(ethylene glycol) macromer is at a concentration of about 28% w/w.

19. A kit comprising:
a plurality of polymer particles in a container,
wherein the plurality of polymer particles comprise a reaction product of:
a poly(ethylene glycol) diacrylamide macromer;
a first monomer; and
a second monomer configured to allow binding of positively charged drugs,

wherein the second monomer is selected from acrylic acid, methacrylic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate, a salt thereof, or a combination thereof;
wherein the plurality of polymer particles are spherical and have a diameter less than about 1,200 μm.

20. A kit comprising:
a plurality of polymer particles in a container,
wherein the plurality of polymer particles comprise a reaction product of:
a poly(ethylene glycol) macromer;
a first monomer; and
a second monomer configured allow binding of negatively charged drugs, wherein the second monomer is selected from amino ethyl methacrylate, 2-amino ethyl methacrylate, amino propyl methacrylamide, a salt thereof, or a combination thereof;

wherein the plurality of polymer particles are spherical and have a diameter less than about 1,200 μm.

Assignees

• Terumo Corp

Inventors

• Plotkin Steve
• Cruise Gregory M
• Keeley Edward Michael
• Yu Renee
• Harris Clayton

Classifications

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• C08F290/062

  Polyethers · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title

• C08F220/20

  of polyhydric alcohols or phenols {, e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate} · CPC title

• C08F220/382 Primary

  and containing oxygen, e.g. 2-sulfoethyl (meth)acrylate · CPC title