High surface area fiber media with nano-fibrillated surface features
US-10449517-B2 · Oct 22, 2019 · US
Mixed bed ion exchange adsorber
US11236125B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11236125-B2 |
| Application number | US-201916561453-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 5, 2019 |
| Priority date | Dec 8, 2014 |
| Publication date | Feb 1, 2022 |
| Grant date | Feb 1, 2022 |
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Abstract
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The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.
First claim
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What is claimed: 1. A single housing comprising a packed bed of fibers for purification of biomolecules, said packed bed having a blend of a first chromatography media and a second chromatography media, said first chromatography media comprising fibers having surface pendant functional groups enabling anion-exchange chromatography, and said second chromatography media comprising fibers having surface pendant functional groups enabling cation-exchange or hydrophobic interaction chromatography, or said first chromatography media comprising fibers having surface pendant functional groups enabling cation-exchange chromatography, and said second chromatography media comprising fibers having surface pendant functional groups enabling hydrophobic interaction chromatography. 2. The single housing of claim 1 , wherein said first chromatography media comprises fibers having surface pendant functional groups enabling anion-exchange chromatography, and said second chromatography media comprises fibers having surface pendant functional groups enabling cation-exchange chromatography. 3. The single housing of claim 1 , wherein said first chromatography media comprises fibers having surface pendant functional groups enabling anion-exchange chromatography, and said second chromatography media comprises fibers having surface pendant functional groups enabling hydrophobic interaction chromatography. 4. The single housing of claim 1 , wherein said first chromatography media comprises fibers having surface pendant functional groups enabling cation-exchange chromatography, and said second chromatography media comprising fibers having surface pendant functional groups enabling hydrophobic interaction chromatography. 5. The single housing of claim 1 , wherein the fibers in said first chromatography media are derivatized by adding surface pendant functional groups enabling anion-exchange chromatography, and wherein the fibers in said second chromatography media are derivatized by adding surface pendant functional groups that enable hydrophobic interaction chromatography.
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- What does patent US11236125B2 cover?
- The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a…
- Who is the assignee on this patent?
- Emd Millipore Corp
- What technology area does this patent fall under?
- Primary CPC classification C07K1/18. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).