Method for producing disinfected liver

Patent metadata

Field	Value
Publication number	US-11160286-B2
Application number	US-201916257766-A
Country	US
Kind code	B2
Filing date	Jan 25, 2019
Priority date	Jun 1, 2012
Publication date	Nov 2, 2021
Grant date	Nov 2, 2021

Abstract

The present invention has demonstrated that microorganisms present in a liver can be killed by washing the bile duct and the portal vein with hot water, and then disinfecting the liver using a chlorine-based disinfectant. It has also been demonstrated that sterilizing effects can be enhanced by freezing the liver after disinfection with a chlorine-based disinfectant.

First claim

The invention claimed is:

1. A method for killing microorganisms present in a bile duct and in a portal vein of a liver, which comprises the steps of:
(a) infusing hot water into both the bile duct and the portal vein of a liver removed from a non-human animal, wherein the hot water has a temperature from 55° C. to 90° C., and the pressure is from 0.05 MPa to 0.5 MPa;
(b) infusing a first chlorine-based disinfectant into both the bile duct and the portal vein of the liver of step (a), wherein the first chlorine-based disinfectant is selected from the group consisting of:
(i) an aqueous hypochlorous acid having a pH of 4 to 7,
(ii) a composition comprising sodium hypochlorite with a pH of 8 to 10, and
(iii) a composition comprising sodium chlorite, sodium hypochlorite, sodium carbonate, caustic soda, and sodium bicarbonate with a pH of 8 to 9,

(c) infiltrating the liver with said first chlorine-based disinfectant or a second chlorine-based disinfectant, wherein the second chlorine-based disinfectant is also selected from the group consisting of:
(i) an aqueous hypochlorous acid having a pH of 4 to 7,
(ii) a composition comprising sodium hypochlorite with a pH of 8 to 10, and
(iii) a composition comprising sodium chlorite, sodium hypochlorite, sodium carbonate, caustic soda, and sodium bicarbonate with a pH of 8 to 9,

(d) freezing the liver, and
(e) thawing the liver.

2. The method of claim 1 , wherein the microorganisms cause food poisoning.

3. The method of claim 2 , wherein the microorganism that causes food poisoning is a microorganism selected from the group consisting of Campylobacter , pathogenic Escherichia coli, Salmonella, Shigella, Aeromonas , and Staphylococcus , and hepatitis E virus.

4. A sterilized liver tissue obtained by the method of claim 1 .

Assignees

• Yamasaki Shinji
• Osaka Nanko Zoki Japan Ltd
• Fuso Pharmaceutical Ind

Inventors

• Yamasaki Shinji
• Hinenoya Atsushi
• Morikochi Iwao
• Yamaguchi Mamoru
• Sakuramoto Yukitoshi
• Nishida Kazumasa
• Asakura Masahiro

Classifications

• A23B4/06 Primary

  Freezing; Subsequent thawing; Cooling · CPC title

• A23B4/24

  Inorganic compounds · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23L13/20

  from offal, e.g. rinds, skins, marrow, tripes, feet, ears or snouts (glands or bones as ingredients of processed meat A23L13/60) · CPC title

• A23B4/08

  with addition of chemicals {or treatment with chemicals} before or during cooling {, e.g. in the form of an ice coating or frozen block} · CPC title