Extracts and isolated compounds from Cakile arabica for treatment of ulcer

Patent metadata

Field	Value
Publication number	US-11147848-B2
Application number	US-201916299683-A
Country	US
Kind code	B2
Filing date	Mar 12, 2019
Priority date	Sep 12, 2013
Publication date	Oct 19, 2021
Grant date	Oct 19, 2021

Abstract

The present invention relates to extracts, compounds isolated from Cakile arabica for use in the treatment of ulcer and to pharmaceutical compositions thereof.

First claim

The invention claimed is:

1. A method for isolating tetracosanoic acid and 4-hydroxy-5-n-butoxy-5-oxopentanoic acid from Cakile arabica , the method comprising the steps:
a. extracting a plant material of Cakile arabica to obtain an extract;
b. concentrating the extract to obtain a concentrate;
c. chromatographing the concentrate into fractions; and
d. isolating fractionated compounds tetracosanoic acid and 4-hydroxy-5n-butoxy-5-oxopentanoic acid.

2. The method according to claim 1 , wherein the plant material comprises the aerial parts of Cakile arabica.

3. The method according to claim 1 , wherein extracting is carried out by using at least one organic solvent, selected from the group consisting of petroleum ether, heptane, hexane, ethanol, isopropanol, methanol and mixtures thereof, preferably is ethanol.

4. The method according to claim 1 , wherein chromatographing is carried out by means of thin layer chromatography (TLC) and/or column chromatography.

5. The method according to claim 4 , wherein said chromatographing is carried out with an eluent selected from the group consisting of petroleum ether, heptane, ethanol, methanol, benzene, diethyl ether, chloroform, dichloromethane, water and/or mixtures thereof.

6. The method according to claim 4 , wherein said chromatographing is carried out with a stationary phase selected from the group consisting of silica gel and aluminum oxide, or mixtures thereof.

Assignees

• Univ King Saud

Inventors

• Shafeek Awaad Amani
• El-Meligy Reham Moustafa
• Marzouk Mohammed Sobhy
• Alotaiby Shroog Mohamed

Classifications

• A61K2236/33

  involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones · CPC title

• A61K31/22

  of acyclic acids, e.g. pravastatin · CPC title

• C07C51/47

  by solid-liquid treatment; by chemisorption · CPC title

• A61P1/04

  for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants · CPC title

• A61K2236/00

  Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine · CPC title