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US-9393225-B2 · Jul 19, 2016 · US
Method for delivery and use of isothiocyanates for prophylaxis and/or therapy of bladder cancer
US9486434B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9486434-B2 |
| Application number | US-201213609531-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 11, 2012 |
| Priority date | Mar 11, 2010 |
| Publication date | Nov 8, 2016 |
| Grant date | Nov 8, 2016 |
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Abstract
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Provided is a composition that contains a mixture of broccoli seed and mustard seed. Before mixing the broccoli seed with the mustard seed, the broccoli seed is subjected to baking and a pressurized heat treatment. The broccoli seed is baked at a temperature of at least 200 degrees Fahrenheit for at least 60 minutes, and is subjected to a pressurized heat treatment of at least 200 degrees Fahrenheit at a pressure of at least 10 pounds/square inch for at least 5 minutes. Also provided is a method for therapy and/or prophylaxis of bladder cancer in an individual. The method entails administering orally to the individual a composition that contains an isothiocyanate (ITC) or a derivative thereof such that the administration inhibits the growth and/or recurrence of bladder cancer. Nutraceutical compositions are also provided.
First claim
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We claim: 1. A composition comprising a mixture of broccoli seed and mustard seed, wherein the broccoli seed has been subjected to baking and a pressurized heat treatment before being mixed with the mustard seed, wherein the broccoli seed was baked at a temperature of at least 200 degrees Fahrenheit for at least 60 minutes before being mixed with the mustard seed, and wherein the broccoli seed comprises heat inactivated epithiospecifier protein (ESP), and wherein the mustard seed has not been subjected to a heat or pressurized treatment, and wherein the broccoli seed is present in an amount effective to inhibit growth of bladder cancer an individual in need of thereof. 2. The composition of claim 1 , wherein the pressurized heat treatment comprises a pressurized steam treatment at a temperature of at least 200 degrees Fahrenheit at a pressure of at least 10 pounds/square inch (p.s.i.) for at least 5 minutes. 3. The composition of claim 1 , wherein the broccoli seed comprises at least 90 micromoles/gram glucoraphanin. 4. The composition of claim 1 , wherein the mustard seed comprises at least 90 micromoles/gram sinigrin. 5. The composition of claim 1 , wherein the mixture of the brocolli seed and the mustard seed is powdered. 6. The composition of claim 1 , further comprising horseradish meal or powder, wasabi powder, or a combination thereof.
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- What does patent US9486434B2 cover?
- Provided is a composition that contains a mixture of broccoli seed and mustard seed. Before mixing the broccoli seed with the mustard seed, the broccoli seed is subjected to baking and a pressurized heat treatment. The broccoli seed is baked at a temperature of at least 200 degrees Fahrenheit for at least 60 minutes, and is subjected to a pressurized heat treatment of at least 200 degrees Fahre…
- Who is the assignee on this patent?
- Zhang Yuesheng, Bhattacharya Arup, Tang Li, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/26. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 08 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).