Chemical modification of analyte permeable membrane for enhanced oxidative stability

Patent metadata

Field	Value
Publication number	US-11109779-B2
Application number	US-201816009963-A
Country	US
Kind code	B2
Filing date	Jun 15, 2018
Priority date	Dec 28, 2012
Publication date	Sep 7, 2021
Grant date	Sep 7, 2021

Abstract

A sensor that may be used to detect the presence, amount, and/or concentration of an analyte in a medium within an animal. The sensor may include a sensor housing, an indicator element embedded within and/or covering at least a portion of the sensor housing, and a membrane over the indicator element. The sensor may include one or more of a first coating on an inner surface of the membrane, a second coating on an outer surface of the membrane, and a layer on the outside of the indicator element. One or more of the first coating, second coating, and layer may reduce deterioration of the indicator element by catalyzing degradation of reactive oxygen species (ROS). The one or more coatings on the membrane may increase the light blocking capability of the membrane, which may improve the accuracy of the sensor.

First claim

What is claimed is:

1. A sensor comprising:
a sensor housing;
an indicator element embedded within and/or covering at least a portion of the sensor housing;
a membrane over at least a portion of the indicator element, wherein the membrane comprises an inner surface and an outer surface;
a coating on one of the inner and outer surfaces of the membrane, wherein the coating reduces deterioration of the indicator element by catalyzing degradation of reactive oxygen species (ROS); and
a layer on the outside of the indicator element, wherein the layer is between the indicator element and the membrane and reduces deterioration of the indicator element by catalyzing degradation of ROS.

2. The sensor of claim 1 , wherein the coating is on the outer surface of the membrane.

3. The sensor of claim 1 , wherein the coating is on the inner surface of the membrane, and the layer is between the indicator element and the coating on the inner surface of the membrane.

4. The sensor of claim 3 , wherein the coating is a first coating, the sensor further comprises a second coating on the outer surface of the membrane, and the second coating reduces deterioration of the indicator element by catalyzing degradation of ROS.

5. The sensor of claim 4 , wherein the first and second coatings are sputter coatings.

6. The sensor of claim 4 , wherein the first and second coatings comprise platinum.

7. The sensor of claim 1 , wherein the coating is a sputter coating.

8. The sensor of claim 1 , wherein the coating comprises platinum.

9. The sensor of claim 1 , wherein the layer comprises platinum.

10. The sensor of claim 1 , wherein the layer is sputtered on the outside of the indicator element.

11. The sensor of claim 1 , wherein the membrane with the coating on one of the inner and outer surfaces of the membrane is opaque.

12. The sensor of claim 1 , wherein the membrane is attached to the sensor housing.

13. The sensor of claim 12 , wherein the membrane is attached to the sensor housing by heat bonding or with a biocompatible adhesive.

14. The sensor of claim 12 , wherein the membrane is attached to the sensor housing using laser bonding.

15. The sensor of claim 1 , wherein the membrane is a mesh material.

16. The sensor of claim 1 , wherein the membrane has pores configured to substantially prevent white blood cells from passing through the membrane but to permit the analyte to pass through the membrane.

17. The sensor of claim 16 , wherein the analyte is glucose.

18. The sensor of claim 1 , wherein the membrane is wrapped around the indicator element.

19. The sensor of claim 1 , wherein the indicator element is a polymer graft including indicator molecules.

20. The sensor of claim 1 , wherein one or more of the membrane and the coating are configured to block (i) external light from reaching the indicator element and (ii) light from the sensor housing that has passed through the indicator element from reaching the bodily tissue of the living animal.

Assignees

• Senseonics Inc

Inventors

• Emken Jeremy
• Huffstetler Philip
• Whitehurst Todd
• Hinds Masika
• Mortellaro Mark
• Chavan Abhi
• Hays Bryan

Classifications

• A61B2562/18

  Shielding or protection of sensors from environmental influences, e.g. protection from mechanical damage · CPC title

• A61B2562/185

  Optical shielding, e.g. baffles · CPC title

• A61B5/1459

  invasive, e.g. introduced into the body by a catheter · CPC title

• A61B5/746

  Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms · CPC title

• A61B2560/0219

  of externally powered implanted units · CPC title