Particles

Patent metadata

Field	Value
Publication number	US-10792390-B2
Application number	US-201916717965-A
Country	US
Kind code	B2
Filing date	Dec 17, 2019
Priority date	Mar 26, 2015
Publication date	Oct 6, 2020
Grant date	Oct 6, 2020

Abstract

Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.

First claim

We claim:

1. An embolic composition including:
embolic particles including a reaction product of a prepolymer solution including:
a poly(ethylene glycol) diacrylamide macromer, a poly(ethylene glycol) diacrylate macromer, a poly(ethylene glycol) dimethacrylate macromer, a poly(ethylene glycol) dimethacrylamide macromer, or a combination thereof;
at least one monomer, and
a visualization agent,
wherein the embolic particles have a diameter between about 40 μm and about 1,500 μm.

2. The embolic composition of claim 1 , wherein the visualization agent is particles of radiopaque materials or halogen containing monomers.

3. The embolic composition of claim 2 , wherein the halogen containing monomer is an iodine containing monomer.

4. The embolic composition of claim 3 , wherein the iodine containing monomer has a structure:

5. The embolic composition of claim 2 , wherein the particles of radiopaque materials include barium, bismuth, tantalum, platinum, and gold.

6. The embolic composition of claim 2 , wherein the particles of radiopaque materials include barium sulfate.

7. The embolic composition of claim 2 , wherein the particles of radiopaque materials include bismuth.

8. The embolic composition of claim 1 , wherein the diameter is between about 400 μm and about 1,500 μm.

9. The embolic composition of claim 1 , wherein the at least one monomer includes ionic groups.

10. The embolic composition of claim 9 , wherein the monomer containing ionic groups is sodium acrylate.

11. The embolic composition of claim 1 , wherein the prepolymer solution further includes a crosslinker.

12. The embolic composition of claim 11 , wherein the crosslinker is biodegradable.

13. The embolic composition of claim 11 , wherein the crosslinker has a structure:

wherein each n is independently 1-20;

wherein d, e, and f are each independently 1-20; or

14. The embolic composition of claim 1 , wherein the macromer is a crosslinker.

15. The embolic composition of claim 1 delivered through a catheter.

16. The embolic composition of claim 15 , wherein the catheter is a microcatheter.

17. The embolic composition of claim 15 , wherein the catheter includes a flow diverting stent formed of a material having a pore size.

18. The embolic system of claim 17 , wherein the pore size is less than the diameter of the embolic particles.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Plotkin Steve
• Wu Xinping

Classifications

• A61L24/06 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds {(A61L24/043, A61L24/046 take precedence)} · CPC title

• A61L2430/36

  for embolization or occlusion, e.g. vaso-occlusive compositions or devices · CPC title

• C08F222/385

  Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide · CPC title

• A61L24/001

  Use of materials characterised by their function or physical properties · CPC title

• C08L33/10

  Homopolymers or copolymers of methacrylic acid esters · CPC title